While it is known that high doses, much higher than Advair™ Diskus® (fluticasone
propionate and salmeterol) Inhalation Powder 500/50, of long-acting bronchodilator medicines, such as the Serevent® (salmeterol) in Advair™ Diskus® (fluticasone propionate and salmeterol) Inhalation Powder, can cause abnormal heart rhythms, this is rare.