Tarceva blood brain barrier

Common Questions and Answers about Tarceva blood brain barrier

tarceva

Avatar n tn did she have lung and rain cancer to or just lung ? my doc said no to tarceva cause it spred to brain i was wondering maybe was this the same as your mom?
Avatar n tn m doing research as quickly as I can to help she and her husband make an informed decision about what to do...if anything. The local drs are recommending 4 weeks of full brain radiation followed by tarceva. Prior to the finding the mets, they were planning 6 weeks of radiation to the right lung in combination with etoposide and cisplatin. I'd appreciate any feedback. My thanks in advance to all responses....
Avatar n tn Thanks for your response. To clarify: his treatment was adjunctive. At the time they saw no sign of cancer outside the lung. Now, however, after 4 rounds of chemotherapy the disease seems to have spread during treatment with taxotere and cisplatin: it's now in the liver, bones and adrenal glands. His original tumor was EGFR positive that is why Tarceva came up as a viable second step.
Avatar n tn She has done very well with chemo and radiation until recently. She was started on Tarceva about 3 weeks ago. Recently, she has been experiencing a lot of confusion. I cannot find anywhere that this is a side effect of Tarceva (it is the only drug she is on at this time). Is it possible that she has a brain metastases? If not, what are the likely causes.
Avatar f tn Because our brain and spinal column is separately by this "blood brain barrier". Keeps critters 'n stuff (that's a scientific term, where I come from) present in our bodies from entering the brain and spinal column. I don't know the answer to that question, though.
Avatar f tn If the node is positive for cancer metastases, this may imply disease progression in spite of Tarceva intake. Tarceva may have to be replaced with another more effective chemotherapy drug. Radiation therapy to shrink the node and relieve the swelling may also have to be done. Consult with your oncologist as soon as possible so you can be properly assessed.
365470 tn?1232747095 Hi all just want to keep you posted , my husband started on the drug Tarceva since his lung cancer is in operable this is supposed to dry up the blood flow to the tumor so it will shrink, so just praying that it does and all goes well, then he will have chemo, the oncologist said no to radiation.
Avatar n tn 4 rounds of chemo of taxotere and cisplatin seem to have not worked as now he has mets in his liver, bones and adrenal glands. His doctor is aftraid that Tarceva is not recommended to someone with mets to the bone. That is not what I read. Can you please let me know if Tarceva is for him and whether that can hep stop or slow down the disease? Thanks.
Avatar m tn since then the diesies showed improvment and shrinkage in tumor. . HE has been under maintance treatment with Tarceva since 2009 upto now. the previous PET-CT ON JULY 2011 WAS NEGATIVE AND CONCLUSION was that no evidence of residual hypermetabolic disease seen in lung.. but the recent CT showed smal new lesion 1,8 *2 cm. in comparison to previous.and his new PET -CT in TURKEY hospital FN shows new FDG(+)SUV max:5) pulmonary nodule in the lower lobe of the lung.
1042487 tn?1275279899 Brain tumors, unfortunately, do not respond to any known treatment. The blood-brain barrier performs a neuroprotective function by tightly controlling access to the brain; consequently it also impedes access of proteins as well as pharmacological agents to cerebral tissues. In order to treat brain tumors, it is therefore imperative to find vectors that can penetrate the blood–brain barrier and permit medications to do their part.
Avatar n tn My husband was diagnosed with a Pancoast tumor on his lung. He went thru chemo/ radiation and finally had surgery to remove the tumor. It was successful. He had more chemo for precaution. After one year, the cancer came back into his Adrenal Gland. It is also in his Lymph Nodes. They put him on Tarceva( a pill he took everyday) And after 6-7 weeks, he had tests done which showed it didn't do anything.. the tumor has grown. They said there is no other options..
382218 tn?1341181487 Hi All, I was reading one of my books on MS yesterday, and had a light bulb moment when reading the discussion of the blood-brain barrier. The author talked about the theory that a trauma can damage the BBB, triggering (not causing) the onset of MS, in someone who is already genetically predisposed to the disease. It was the examples given of what constitutes trauma (“a car accident OR a fall”), that gave me pause.
8398640 tn?1398042546 The protein in question is involved in regulating which immune white cells get across the blood-brain barrier to be able to cause inflammation in the brain. Women appear to allow more of the very inflammatory cells across - T-cel lymphocytes. This fits in with Tysabri's mechanism of action. Tysabri blocks T- lymphocytes from passing across the barrier from the blood into the brain. Tysabri is probably the most effective of all the DMDs discovered to date.
Avatar n tn you have Lyme, it is already entrenched behind the blood-brain barrier. The Lyme spirochete invades theCSF and can penetrate the blood-brain barrier within 12 hours of infection. Insist on full Western Blot, PCR, or one of the newer and more reliable tests. MD’s are still letting patients die or suffer debilitating, crippling illness because they are clueless as to how to test for, diagnose, and treat Lyme & other tick-borne diseases.
Avatar n tn In 2005, he had Tarceva. In 2008 they discovered metastasis to the liver (3 lesions) and he underwent chemo again (I think Avastin) and he finished the treatment in March. The doctor said the tumors in both the lungs and liver were smaller. For the past 3 weeks he´s been vomiting, but sporadically. There is no pattern. It doesn´t matter if he eats lightly or heavily. Some days he vomits once, some days nothing. He went to see a Gastroenterologist. They did a sonogram...
Avatar m tn He started Tarceva this January but it seems it did not work as the cancer spread to brain…. 9 mets were identified in the initial MRI 2 weeks ago but the subsequent MRI right before yesterday’s gamma knife procedure (which removed 7 mets) evidenced numerous other tiny/small tumors spread all over the brain….He has been in relatively good condition (eating well, no weight loss) until these new mets emerged (which affected his walking and reading ability)….
Avatar f tn ) as the number of times a virus has crossed the blood brain barrier. They take a blood draw, and take a sample of spinal fluid, and through a special test they're able to draw out these bands. (Each band is a different set of antibodies for a specific virus.) The blood-brain barrier is the tentorium that your brain sits in. It's basically a skin bag - similar to the stretchy transparent bits you get when you cut up a whole chicken.
Avatar f tn it only effects your intestines and doesn't cross the blood brain barrier. don't take too much of it as it can cause your intestines to become accustomed to the use and you wind up withdrawaling from immodium..
333672 tn?1273792789 I read The Other Brain by R. Douglas Field recently and if you're interested in the brain, this is a fascinating book. He is a cheerleader for glia and research on glia. Glia are all the non-neuron brain and nervous system cells. Glia means glue and glia have been second-class citizens behind neurons in terms of scientific research. They were thought of as bubble wrap for the brain and seen exclusively as supporters of neurons.
Avatar n tn I would suggest to trymagnesium threonate for potential benefits to neural and brain health. May be magnesium chloride may not cross the blood brain barrier effectively but it can support in cognitive function.
378497 tn?1232143585 I don't really know. The dura is the tough membrane that encases the outside of the spinal cord. Inflammation there is NOT from MS. It could be from irritation from being touched by an impinging disc. It is not from a break in the blood-brain barrier. The dura's blood supply is on the body side of the blood-brain barrier. Inflammation there should not raise the level of inflammatory antibodies in the CSF. And I don't think it would show up in the CSF.
363281 tn?1643235611 I took GABA and it did nothing. I read where it does not cross the blood brain barrier. For these herbs to help with relaxing, that is what must happen. Don't know of too many that do. That will be a good research project. Suntheanine does.