Namaste,
You do not have to be off Anafranil prior to
taking Celexa, although you should not be
taking them together.
Anafranil is one of the older forms of anti-depressant called a tricyclic, whereas Celexa is one of the newer SRRI's.
Celexa is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). It works by restoring the balance of serotonin, a natural occuring substance found in the brain, which helps to improve certain mood problems.