Tacrolimus neurotoxicity
Common Questions and Answers about Tacrolimus neurotoxicity
prograf
i wouldnt lower the tacrolimus dose further
Have you done any studies regarding neurotoxicity of adderall and does it affect the motor neurons of the CNS? Are muscle fasciculations a sign of neurotoxicity? I know most fasciculations are benign, but I am worried about the effect that adderall has on the neurons of the body and if it can lead to overstimulation and exhaustion of the neuron. Do you have any knowledge regarding these SPECIFIC issues? Thank You for your time.
The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.
His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys?
Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe?
Sir ,will wait for your kind reply.
Thanks.
s hard to perform my job or other daily tasks when my eyelids are so inflamed. I guess steroids are the only option until they develop something better. Is Tacrolimus a promising nonsteroidal option?
The treatments of this condition are application of topical corticosteroids (betamethasone, clobatesol, flucinolone) which will reduce the inflammatory process. Topical immunomodulators like pimecrolimus and tacrolimus can be used in severe conditions.
I hope it helps. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.
s suggestion and seek help with a well-known homeopathy MD out-of-state. I have contacted this practitioner and he thinks that he can help with B6 neurotoxicity. My appointment is in mid-July. I'll keep the forum posted on how it plays out. I don't believe that it can hurt, (except for all the money to spend), and, maybe it could help. Many folks believe in the knowledge of homeopathy experts. We will see soon. Take care, everyone.
Hormonal contraceptives such as the pill and the patch may increase the blood level of tacrolimus. Tacrolimus may also reduce the effectiveness of these hormonal contraceptives. For this reason women who could get pregnant should ideally use a non-hormonal method of contraception, eg condoms, to prevent pregnancy while taking this medicine. Seek advice from your doctor or pharmacist.
there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.
AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?
Lots of it depend on the substance you were using. Opiates can be very forgiving after you quit. They say that it takes 6 months to 2 years to get fully back to 100 percent....but, things get much better quickly..and the last 10 percent or some comes slowly over months. Benzos can take even longer. Hallucinogenic drugs like Extacy and PCP can cause damage that will never heal. And, the oxygen depriving effect from overdosing on any drug can cause neurological damage that will never heal.
Treatment is by topical steroids or oral therapy of corticosteroids in severe cases. Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful.
If still the symptoms do not improve then please get a clinical examination done by a dermatologist.
I hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.
Someone suggested that that trauma to the sympathetic system of all that freezing ice to the elbow, (when the weather was also freezing) may have set up a flare to my nervous system Also, discovered that I was taking about 200 mg of B6 in various supplements, starting about a few months before the symptoms appeared. Could it be B6 neurotoxicity? Any thoughts on what I could have? Thank you very much.
Not the right place for this question. Sorry.
I was prescribed Dexadrine, but have not tried it yet. I am concerned about neurotoxicity, as well as the possibility of permanent dopamine damage/reduction. The main issue I am struggling with is computational speed. Simply put, I have much difficulty following what an individual says when speaking to me and I need to ask them to repeat it because I cannot process the information quickly enough.
I am taking Tacrolimus 3mg, Myfortic 360mg, twice a day. My Creatine is 1.25 and BUN is 29. I am also interested in your opinion.
I was initially taking Tacrolimus and then I was switched to Sirolimus. I cannot remember why my immunosuppressive was changed but Sirolimus was pretty new then and maybe my surgeon wanted to try it and see how I did. I wasn't very fond of it as I recall. It came in small packets and was an oily solution. It's been a while but I do remember that. I probably mentioned this to my surgeon and that could be the reason that he switched me back.
Another Dermatologist thought my immune system caused the reaction and prescribed Tacrolimus ointment...told me to put it on until the color came back. I did that for 3 months and didn't notice any significant change....only occasional peeling of the skin next to the head of my penis! Is there ANYTHING that will fix my skin?
Also use of antibiotic creams, antihistaminics, sun screens and tacrolimus(available by prescription) helps but consultation of a dermatologist is required first. Also it is not permanent and will slowly go away with proper treatment and lifestyle changes.
I sincerely hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.
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