I believe it can be related. But finding the root cause is very difficult. Something is out of balance. Then when puberty goes into full gear, whatever piece of the puzzle is missing, this seems to effect hormone levels, immune system balance, etc. I see the same thing in my kids...loss of muscle mass, food intolerances, anxiety in one, depression in another, intolerant to carbs, etc. Whatever the problem is, it has a body wide effect.