Your sed rate or (ESR) can be high with any cause of inflammation such as Rheumatoid arthritis, anemia, lupus, pregnancy, etc. Do you have a sore throat
? Have you had your throat
checked for a strep infection? You could also perhaps have mono if you had a sore throat, swollen glands and high fever, fatigue etc. A lot of things will cause high ESR and swollen glands. What other symptoms do you have?