Repair and regeneration begin at 48 hours to 72 hours post-injury, and continue maximally for
six weeks. This is one
of the reasons Prolotherapy injections are given every
six weeksùto maximize the time of proliferation of the new ligament tissue. From six weeks to 12 months the ligament tissue remodels, contracts, and gains tensile strength. After 12 months the ligament and scar tissue generally matures and achieves 50 to 70 percent strength of the original ligament.