I followed a regular routine of warming the site first, swabbing with alcohol, injecting the med at room temp using the autoinjector, and then using an ice
pack for 15-30 mins afterwards. After the first few weeks, the site reactions had improved quite a bit. I continued to follow this same routine.
On my recent trip to the US, I didn't bother using the heat or ice pack as it was too inconvenient. No microwave in the hotel room, and the mini-bar did not have a freezer.