In most cases, the clinical consequence of the pharmacokinetic
interaction has not been evaluated. However, for midazolam
and triazolam, as well as for buspirone, impairment of CNS function was observed, and for the calcium channel blocker felodipine greater blood pressure lowering has been observed. In contrast to the increased levels of the other medications, the grapefruit juice interaction observed with theophylline and itraconazole was reduced plasma concentrations.