Abstract
Epidemiological evidence indicates a significant association between
vitamin D deficiency
and an increased incidence of autoimmune diseases. The presence of
vitamin D receptors (VDRs) in the cells of the immune system and the fact that several of these cells produce the vitamin D hormone suggested that vitamin D could have immunoregulatory properties, and now potent immunomodulatory activities on dendritic cells, Th1 and Th17 cells, as well as B cells have been confirmed.