Simvastatin and grapefruit
Common Questions and Answers about Simvastatin and grapefruit
zocor
I remember reading something about grapefruit and the new protease inhibitors this months ago and therefore I have steered clear of grapefruit juice while on treatment.
VICTRELIS™ (boceprevir) can potentially react with a number of other medications. Some of the drugs that may interact with VICTRELIS include but are not limited to:
P-glycoprotein inhibitors, such as:
Grapefruit juice
http://hepatitis-c.emedtv.com/victrelis/victrelis-drug-interactions.
It was after this that I was put on the simvastatin and metoprolol. I also take aspirin ( full dose ) and flecainide for the afib. Both the metoprolol and flecainide are taken at a low dose.
My readings before I started the simvastatin, were ( 140 total ) HDL 33 LDL 79 and Triglycerides 139 . What has changed is that my HDL has gone down to 24 from 33 LDL has gone down to 65. So basically Everything has gone down, what has him worried is the HDL has gone down.
A Potential for Adverse Events
Many patients may take their medications with a glass of juice. However, since the accidental discovery of an interaction between the calcium channel blocker, felodipine, with grapefruit juice,1 it has now become evident that grapefruit juice has the potential to alter the plasma concentrations of many medications when they are taken by mouth. In some cases, this may result in undesirable clinical effects of medications.
There does seem to be a significant difference in the way different statins affect people. Simvastatin is virtually the 'automatic' version which most doctors automatically prescribe to patients as a starter. Atorvastatin is another common one. Your GP will find one which suits you with regards to side effects but you should stop taking them if you experience discomfort from them and then try another brand.
“If you are unaware that a patient is on simvastatin and you give either boceprevir or telaprevir, the simvastatin level in the blood can go high and patients can develop muscle breakdown,” said Dr. Jensen.
http://www.idse.net//ViewArticle.aspx?
I quit taking the simvastatin last tuesday, and by friday I looked perfectly normal with no steroid cream......
Thanks again for all the help!
m SVR now and can have the lemonade I want to.
I use simvastatin to lower the cholesterol and lisinopril to lower the bp. The lisinopril works w/o the simvastatin and v.v.
Amlodipine is a calcium channel blocker while lisnopril is an angiotensin converting enzyme(ACE) inhibitor. Both groups of drugs and simvastatin are unlikely to cause erectile dysfunction. However yes, all three of them can cause swelling of ankles. Talk to your doctor. You can change your medications. Among antihypertensives you need to avoid thiazides , beta blockers and alpha blockers.
High blood pressure and reduced blood supply to penis can also cause erectile dysfunction.
I have been on 20 mg of simvastatin and 3000 mg niaspan now my ck levels have went from 60 to 295 i could hardly walk .will my levels come down if i lower dose. and reverse damage. i have 12 stents .the rest of my blood work is fine.
My wife has been perscribed fentanyl patches and has been told not to eat grapefruit, does this apply to all citrus fruit ie.
http://www.medhelp.org/posts/Hepatitis-C/Treatment-for-Hep-C--Grapefruit-Juice/show/542498
“It actually can increase some drug levels because of inhibiting a liver metabolic enyzme. However neither interferon or ribavirin is metabolized by that particular enzyme(p450) so it is OK to drink your grapefruit juice. Stay Healthy!
Several of my drugs (Lamictal, Seroquel, & Valium - at a minimum) interact w/ grapefruit. It's on all of the information that comes from the pharmacy and I didn't take it seriously until I got pretty toxic myself. I LOVE grapefruits & grapefruit juice and I miss them a lot. I also tend towards side effects and toxicity.
Wow looks like i should have read the warning label when my doc gave me to take them PRN or as necessary to re convert myself......okay i just went off of the site and read up on the label...they are telling us not to take it with the citrus because it effects how our body absorbs the Multaq for maximum performance of the med...if it were me and i had to take it on a daily basis i probably would stay away from all citrus drinks for sure because you want to give yourself the best shot possible...
This may seem to be a silly question, but has anyone heard from their doctors not to combine methimazole and grapefruit? Online research seems to say it's not flagged as interacting but also notes that no studies have been done to see if it does interact. I was wondering if anyone's doctor had said anything?
My doc is on vacation and I was gifted with a lovely and delicious looking 24 grapefruits.....
Recommended
