Prove 3 is (was) the
first trial held by Vertex for previous non-
responders to SOC tx (see below announcement). I was in the 24 week arm that got VX950 + INF +RBV for 12 weeks followed by 12 weeks of SOC.
Technically I wasn't a non-responder to SOC because I got a 2+log drop by week 4 on SOC, then a slow decline from 3M to 9,600. Around week 32 it went up, viral breakthrough, game over.
Like dmhrdh said, Prove 3 people had previous treated (some multiple times) unsuccessfully.