scopolamine blood brain barrier

I have been on this patch for 3 1/2 years due to dr oversight. long-term used has caused medical problems (tachycardia, gastroparesis, blurred vision, SOB,pupil dialation, really bad memory,etc. Two attempts to withdraw landed me in a er. I am now going into the hospital to withdraw as a medical admit. I contacted a professor who did long-term scop use and he said no one has ever been on it as along as me. he anticipates a very long road.

Because our brain and spinal column is separately by this "blood brain barrier". Keeps critters 'n stuff (that's a scientific term, where I come from) present in our bodies from entering the brain and spinal column. I don't know the answer to that question, though.

Brain tumors, unfortunately, do not respond to any known treatment. The blood-brain barrier performs a neuroprotective function by tightly controlling access to the brain; consequently it also impedes access of proteins as well as pharmacological agents to cerebral tissues. In order to treat brain tumors, it is therefore imperative to find vectors that can penetrate the blood–brain barrier and permit medications to do their part.

He said the scopolamine affected the focusing mechanism in my eye. My blood vessels and eye nerves looked perfect, he said. He could tell my focus distance was off. My OB/GYN sent me to a neurologist. He couldn't determine what was wrong from the office exam, but ordered a MRI and bloodwork, including thyroid tests. I am totally overwhelmed by the possibility that my vision will never be the same again. I am a 38 yr old healthy working mom.

Hi All, I was reading one of my books on MS yesterday, and had a light bulb moment when reading the discussion of the blood-brain barrier. The author talked about the theory that a trauma can damage the BBB, triggering (not causing) the onset of MS, in someone who is already genetically predisposed to the disease. It was the examples given of what constitutes trauma (“a car accident OR a fall”), that gave me pause.

If an underlying cause is not found, anticholinergic medication can help, such as atropine, scopolamine, or even benadryl. The blood in your sputum is concerning, this needs to be checked by your doctor since that does not commonly accompany sialorrhea.

I was put on a scopolamine patch in Sept.'10 and have been wearing it fr the last 8 months. It is pute HELL everytime I try to get off of it. The Dr.s have diagnosed me with Meniere's Disease but I can't get off the patch for them to do definitive testing. My Dr. has put me on an oral for of scopolamine but if I am even an hour or two late taking my dose I am deathly ill. And each tinme I get sick it is worse than the time beforel.

What is the best way to wean off the scopolamine patch in an elderly person? Can we use the cream instead and slowly increase the time between use?

The protein in question is involved in regulating which immune white cells get across the blood-brain barrier to be able to cause inflammation in the brain. Women appear to allow more of the very inflammatory cells across - T-cel lymphocytes. This fits in with Tysabri's mechanism of action. Tysabri blocks T- lymphocytes from passing across the barrier from the blood into the brain. Tysabri is probably the most effective of all the DMDs discovered to date.

you have Lyme, it is already entrenched behind the blood-brain barrier. The Lyme spirochete invades theCSF and can penetrate the blood-brain barrier within 12 hours of infection. Insist on full Western Blot, PCR, or one of the newer and more reliable tests. MD’s are still letting patients die or suffer debilitating, crippling illness because they are clueless as to how to test for, diagnose, and treat Lyme & other tick-borne diseases.

) as the number of times a virus has crossed the blood brain barrier. They take a blood draw, and take a sample of spinal fluid, and through a special test they're able to draw out these bands. (Each band is a different set of antibodies for a specific virus.) The blood-brain barrier is the tentorium that your brain sits in. It's basically a skin bag - similar to the stretchy transparent bits you get when you cut up a whole chicken.

it only effects your intestines and doesn't cross the blood brain barrier. don't take too much of it as it can cause your intestines to become accustomed to the use and you wind up withdrawaling from immodium..

She prescribed scopolamine patch, did nothing. I told her my vision was getting blurry. I went to optometrist since I wear glasses, got new glasses just in case, no improvement. CT with contrast and inner ear normal. First neurologist said I have something like disembarkment syndrome but I did not disembarkment anything. She prescribed Clonazepam and a medrol pack, both of which did nothing.

Hi Gina, It is definitely from the scopolamine. I have been on 16 cruises and everytime I have stopped the scopolamine I have the same symptoms of extreme fatigue. The first 24 hours after I stopped the medication there was no problem, but when I awoke the next day I was really out of it. I do not suffere from the nausea or headache that you have encountered. It usually subsides after about 6 weeks.

I read The Other Brain by R. Douglas Field recently and if you're interested in the brain, this is a fascinating book. He is a cheerleader for glia and research on glia. Glia are all the non-neuron brain and nervous system cells. Glia means glue and glia have been second-class citizens behind neurons in terms of scientific research. They were thought of as bubble wrap for the brain and seen exclusively as supporters of neurons.

I would suggest to trymagnesium threonate for potential benefits to neural and brain health. May be magnesium chloride may not cross the blood brain barrier effectively but it can support in cognitive function.

I don't really know. The dura is the tough membrane that encases the outside of the spinal cord. Inflammation there is NOT from MS. It could be from irritation from being touched by an impinging disc. It is not from a break in the blood-brain barrier. The dura's blood supply is on the body side of the blood-brain barrier. Inflammation there should not raise the level of inflammatory antibodies in the CSF. And I don't think it would show up in the CSF.

I took GABA and it did nothing. I read where it does not cross the blood brain barrier. For these herbs to help with relaxing, that is what must happen. Don't know of too many that do. That will be a good research project. Suntheanine does.

“Vertigo is usually associated with a problem in the inner ear balance mechanisms (vestibular system), in the brain, or with the nerve connections between these two organs. Vertigo can be a symptom of an inner ear infection or of an underlying harmless cause.

t very successful in crossing the blood-brain barrier. When the FDA banned it because of a tainted batch and left it banned for years, 5HTP from a plant was discovered and became the favored way to take it because it does cross the blood/brain barrier. But it seems whatever form you're using is working, you are metabolizing it, and it's making you tired, as it's supposed to do. This might wear off over time, it might not.

Thanks DV , that was interesting. The blood brain barrier thing still has me stumped.

[4] Loperamide molecules do not cross the blood-brain barrier in significant amounts, and thus it has no analgesic properties. Any that do cross the blood-brain barrier are quickly exported from the brain by P-glycoprotein (Pgp), also known as multidrug resistance protein (MDR1). Tolerance in response to long-term use has not been reported. However, loperamide can cause physical dependence.

Interesting question. Loperamide does not cross the blood brain barrier & I believe that sub primarily acts on the opiate receptors in the brain so theoretically, there is no cross-over.

Scopolamine blood brain barrier

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