Recurrent UTI, with or without VUR, is the most common reason for long-term antibiotic prophylaxis
in infants and children. However, the efficacy and importance of long-term antibiotic prophylaxis
have not been assessed in well-controlled, prospective studies. Nitrofurantoin, trimethoprim/sulfamethoxazole have been used as prophylactic antibiotics for the prevention of UTI in children. Such medications are mostly safe in children for the long-term prophylactic therapy.