Effective doses are high doses, often hundreds of times more than the US Recommended
Dietary Allowance (RDA) or Daily
Reference Intake (DRI). Abram Hoffer, M.D., Ph.D., comments: "Drs. Wilfrid Shute and Evan Shute recommended doses from 400 IU to 8,000 IU of vitamin E daily. The usual dose range was 800 to 1600 IU but they report that they had given 8,000 IU without seeing any toxicity." The Shutes successfully treated over 35,000 patients with vitamin E.