Hypermagnesemia, hypomagnesemia,
and increased tendon reflexes have been reported in infants whose mothers were using aluminum
and magnesium containing antacid products chronically and in high or excessive doses during their pregnancy. No congenital defects have been reported with the use of simethicone. Animal studies with simethicone-coated cellulose suspension have not revealed maternal or fetal toxicity; however, animal studies are not always predictive of human risk.