I always took my thyroid med first thing when I got up, then my Aciphex
and BP meds about an hour later. What you really have to watch out for
and make sure you keep the 4 hour separation is vitamins/minerals, such as calcium, magnesium, etc.
I currently take my BP med and fluid pill, along with my T3 med, about an hour after my Tirosint (T4).
You could also try taking your Protonix at night, if you really want to keep that separation.