The good thing is that you
missed the estradiol and not the
prometrium. Estrogen stays around in the body much more than progesterone does. My estrogen was in twice-weekly shots, and when I asked my doctor why they prescribed that I take them Wednesday evening and Sunday evening (clearly not exactly the halfway point in a given week, it was an every third day, every fourth day schedule) I was told there was still residual estrogen from the last shot even by the fourth day.