Prograf levels high
Common Questions and Answers about Prograf levels high
prograf
I'm 61 years young and had a full liver transplant 2 1/2 months ago. Prograf levels go from 7 to 13.6 back to 6.5 Could it be the new lab that is screwing up. I take all 52 pills on time dailywith a wonderful hubby making sure.
you sound like you may be on a bit too much immunosuppression this many years out from the transplant. a lot depends on the prograf and rapa trough levels though. i recommend aggressively talking with the transplant team about lowering the doses of both. not sure frankly why you need to be on both rapa and prograf.
My history: liver transplant 1 year ago, had 2 moderate rejections and 1 mild since transplant. At present time having moderate rejection, recently had one portal stent and 8 Bilary ERCP's to remove stones and sludge and had stenting done, and at the present time there are no blockages. Was on Rapamune (5mg a day) prior to hernia surgery and then week before hernia surgery was put on Prograf (4mg a day) and taken off the Rapamune. I have been on Progaf since hernia surgery (8 weeks ago).
Prograf is a medicine that slows down the bodys immune system. For this reason, it works as an anti-rejection medicine. Prograf helps patients who have had a liver/kidney transplant protect their new organ and prevent it from being rejected by the body. This medicine can cause the amount of potassium in your blood-stream to increase.
If i lower my prograf lower than 6.5 through rate i start getting discomfort right side .i am having cognitive issues on prograf that are getting very hard to live with, seems like it got alot worse after my last of three mri with contrast in two years. was hospitalized two days after last contrast exsposure white blood count went to1000, headach, fever urine got exstremly foamy, severe itching ,tighting and rashd eveloped on lower legs two weeks after.
Pentamidine (aerosol) 1x monthly, Prograf 2mg 2x daily, metroprolol tartarate 12.5mg 2x daily, magnesium oxide 400mg 2x daily, oscal, multi vitamin, vitamin d3 1000iu 1x daily. Thanks.
I agree with everything above except that i am unaware of it affecting the levels of immunosuppressive medications. in addition, there is growing evidence that it may be increase liver fibrosis.
My current dose is Prograf 3 mg AM/ Prograf 3 mg PM and Rapamune 4 mg AM. The intent is to convert me to 100% Rapamune because of the nephro-toxicity of the Prograf and my young age and because of the anti-cancer properties of Rapamune. Data, while horribly limited, has shown Rapamune's anti-cancer properties have had success against vascular tumors such as mine so EHE, in this case chronic, is part of the cancers Rapamune affects (some cancers it has no effect).
I believe that the benefits pf statins outweigh the risks and have altered my eating lifestyle so to nearly exclude carbohydrates. This has enabled me to continue statin regime while keeping my fasting blood glucose levels at acceptaptable unmedicated levels. My wife on the other hand continues to take Metformin while on the statin drug.
Have reduced prograf levels in last 7 months from 8 and change to 4 and change ,from 3 mg twice to 1 mg twice. Could this have some bearing? Moved and changed post transplant care. Untreated pleural effusion for one year in hopes it would go away on its own.Once thorocentisis was initiated the first couple of times a liter was drained. Total seven thorocentisis were done the last two 300 cc were drained and they said the remaining fluid was lockulated .
t understand the relationship between treatment and Prograf dose. It sounds logical to think that the higher the Prograf dose the less likely TX will be successful and, at the extreme, I think that's probably true. But, whether 3 mg per day or 6 mg Prograf per day makes any difference is a question I cannot answer.
When I treated there was a reluctance to dose the way a non-transplant patient would have been dosed and that can be and, in my case, was problematic.
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