Pristiq and the liver

Common Questions and Answers about Pristiq and the liver


Avatar f tn Desvenlafaxine succinate, marketed under the name Pristiq, is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class from Wyeth (the makers of Effexor). It is a metabolite of venlafaxine (Effexor). It is said to have less side effects than Effexor and better absorbed according to my doctor,but clinical trials and any reserach I have done do not state that. It seems that they are prety much the same.
Avatar m tn I've read the side effects and dangers for both, but am uncertain which one to go with. Pristiq seems like it's very similar to Effexor, so would it have the same sexual side effects? And Cymbalta seems great until you read the part where your liver can explode if you drink alcohol (I rarely drink), plus it has also been used to treat chronic pain, which I do have. So, has anyone taken either or both? And which one has worked better for you?
Avatar m tn You must know that one size does not fit all concerning drugs. Some people had a bad experience with Lexapro and went to Cymbalta and it was a life saver and the same is true for Cymbalta. Final word, I woud choice between Lexapro and Cymbalta and you must note that i'm not a doctor and you should talk about it with you doctor prior making a decision.
Avatar f tn From what I have read and heard from almost every doctor most antidepressants are safe for the liver. There are noted dose changes for people with liver disease on some of the drugs but overall they are safe. However anyone can react to a drug diffrent than others have, so a follow up blood test is always recommended. I do however know of one drug, Cymbalta, has been flaged by the FDA as not safe for anyone with liver disease.
Avatar f tn I was on 100mg per day for 4 years, then have reduced it myself to 25mg a day. The liver enzymes were still elevated and and an ultrasound showed fatty liver disease. There is no scarring, and don't want there to be. The odd thing is that I tried a couple of generics and they went down. The generic did not do the job, so I switched back to name brand. I have gained 14 pounds in the 6-7 months I have been on the name brand Pristiq again, and the enzymes went up a bit.
Avatar f tn What your doc has seen is the new info on Cymbalta that came out when the manufacturer applied for an additional approval for fibromyalgia and other pain sufferers and the FDA committee discovered at least a dozen liver deaths from Cybalta. But Pristiq, which is the new and improved Effexor, might have the same not yet revealed problem. In the old days, when tricyclics were the rage, everyone on them had to get their liver enzymes checked regularly. Most meds are liver toxic to an extent.
Avatar n tn ) The other antidepressant my liver doc approved was Effexor because it helps with depression and anxiety and has a short life, and Xanax. I was under the impression most liver docs will work with you re suggesting antidepressants and even have liver-friendly psychiatrists they routinely refer to. Of course this would be typical in a large city setting (I'm in a Houston). Not loosing weight, drinking plenty of water and following a healthy diet are also essential.
Avatar m tn bottom all day long, bloating, some soft stools, anxiety. I was on Remeron since the first week of September and dropped it because my Liver Function tests came back high. I was also taking a whole bunch of supplements at the time and don't know what caused the high numbers so I dropped every pill. The Remeron didn't seem to have any positive or negative affect on me.
Avatar m tn bottom all day long, bloating, some soft stools, anxiety. I was on Remeron since the first week of September and dropped it because my Liver Function tests came back high. I was also taking a whole bunch of supplements at the time and don't know what caused the high numbers so I dropped every pill. The Remeron didn't seem to have any positive or negative affect on me.
Avatar m tn says, hang in there, keep doing what your doing and soon a cure should be available. I am geno type 1 and was given the interferon/ribovirin treatment for 6 mts. No change and after taken off I was already bed/couch ridden with very little energy. Then I began a quest to research this myself and found like most that all hygiene products have 3 to 20 or more chemicals a challenged liver cant deal with. Changed all those products to near nat.
Avatar n tn It is the active metabolite of amitriptyline that is demethylated in the liver. It is kinda like ''the new amiltriptyline with less side-effects.
Avatar f tn Did he have these night time problems before the addition of Prozac? I am guessing he did not for the reason given below. Get him off the Prozac (but do so slowly). The Prozac blocks the liver pathways for the stim meds and will make things worse. This is a quote from Dr. Charles Parker. I will private message you the site as I can't post it here.
Avatar f tn BUT-one side effect of Effexor can be hepatitis B and even liver failure. Pristiq is not metabolized by the liver. People with the 'missing enzyme' might do better on Pristiq than Effexor. It goes straight to the blood stream so it may be used to treat major depression more quickly. Pristiq is less likely to have as many drug to drug interactions as Effexor does. Pristiq has more affect on the seratonin system than Effexor does.
Avatar m tn But, there is a lot of bad press as they don't seem to understand the difference between the brain differences (and thus the need) for them. Your Adderall dose is not that high. But taking two xr is weird. The duration of xr should be about 8 hours. If it is much less then that, then its a good sign that you are underdosed. If if is lasting that long, then a normal adderall with a duration of 4 to 6 hours should be fine. Kind of doubt that you need 16 hours of coverage.
Avatar n tn I probably shouldnt have another one but my husband and I are going to try the end of the summer. The labor and delivery I was really worried about but that was the easy part. I did get dizzy towards the end of pushing but overall I did fine. My only advice is to make sure you are well hydrated drink drink drink drink drink. It was hard for me because I was so nauseous all the time but keeping hydrated is the best thing for u.
903604 tn?1274721174 for Schizoaffective disorder, anxiety, ADD, high blood pressure, depression (yes, I really am only 31), Do any of you out there have chronic pain treated with meds PLUS hep C? What is the long term damage to the liver, and how long can it keep repairing itself before it just tires out and begins to become fibrotic? Are there effective ways to treat chronic pain from DDD, ruptured discs, fragments, etc. that don't require meds and won't harm the liver?
Avatar n tn I've gained significant weight while on these drugs (despite an intense exercise program and careful diet). My nutritionist and MD told me that the drugs likely altered my metabolism, but no one can tell me how long it will take to correct that. Most frustrating, I've noticed that since I stopped taking both, my weight gain has accelerated. Any ideas as to how long I need to endure this or ideas for correcting my metabolism? Thanks.
147426 tn?1317269232 The classic one is a painless (oddly enough) but distinctly electrical shock making a semicircle around my eye and running into the side of my nose and then down into my upper lip. That began around the same time as my other symptoms (fall 1999) as two separate little shocks above and below my left eye and gradually progressed to the eye/temple-nose-lip distribution. Also on the right side, but much less frequently.
Avatar n tn On the positive side, Effexor is an amazing antidepressant, I tried wellbutrin first and it didn't help compared to the Effexor. Everyone is different, Effexor is know for having the worst withdrawl so you need to make sure the DR. takes you off it slowly. Good Luck!
Avatar m tn What was appealing about this guy was that he did genetic testing, serum testing, toxicology testing, transcranial magnetic stimulation and biofeedback. He wanted me to take Deplin and Pristiq. I opted not to take the Pristiq, but to take the Deplin. My decisions were based on discovering that people had a hard time coming off Pristiq. I also had high norepinephrine and wasn’t sure that was the best med. I opted to just take the Deplin.
Avatar n tn The dizziness resembled being carsick, with lightheadedness and occasional moments of nausea and feeling faint (but I never passed out). I had a CAT scan and blood work twice, and so far no diagnosis for the dizziness/fatigue. It got better for a few weeks but last week I began to have dizzy spells again, this time accompanied by maxillary sinus pressure. I had just switched allergy medications, from Nasonex to generic Flonase, right at the time my symptoms returned.
5093508 tn?1390547531 Yes, I know about Serotonin Syndrome and had experienced the beginnings of it last year when I was prescribed Pristiq, then Lexapro, and finally Seroquel, which really put me over the edge. I weaned myself off the lot, as I was so ill, mentally and then physically. All this was prescribed on top of 60mg Mirtazapine. I tried to get my GP to have me put in hospital, as I did think I was having Serotonin Syndrome, as I was vomiting, couldn't eat, and was skin and bone and dying I reckon.
975514 tn?1325001538 I knew I wasn't depressed and had had bad experiences before with being prescribed them based on past misdiagnoses of depression as the etiology of my pain. however, I gave the new doctor the benefit of the doubt and tried the savella and my pain vanished almost immediately. I'm having some side affects, but they seem to be gradually diminishing. I've been on it for about 2 months and it's still freaky to realize that there's no constant pain.
Avatar n tn I read where this could be a problem with the liver. Should he talk to the doctor about having a liver test. Is this drug broken down through the liver?
Avatar m tn It seems to show up mostly when my eyes are moving and the light/background conditions are changing. Once my eyes are steady and fixed on something, the spot disappears. But if I, say, look up from the computer screen, and then back down at it....the spot appears again.
997735 tn?1250019778 However, the pain I'm in is completely off the scale and totally debilitating. I'm on Soma and Lortab and they only just take the edge off. Compared to my physical activities of 2 1/2 years ago, i.e. swimming, a work-out-a-holic, rock climbing, etc. I would now consider myself a cripple. My pain is from the bottom of my rib cage in my back, up my spine, into my neck and stops, I guess, at the very top of my spine.
Avatar f tn On one hand I stay off medications and take the chance of me harming myself to let my liver heal and on the other hand, cause more damage to my liver and relieve the panic attacks and depression. I feel so lost and hopeless in this situation. Are there any natural ways to level my moods out that won't harm my liver that will help with the panic attacks and depression? I truly need help because my symptoms are getting worse by the day.
881463 tn?1245349249 The 'dorsal columns' run on the dorsal surface of the cord; they carry sensation from the legs, and as you move higher also from the chest and arms. The thing is, the sensations carried in those pathways are touch and vibration sensation, not so much pain sensation. Pain sensations are carried by pathways deep within the spinal cord called the 'spinothalamic tract'.
544292 tn?1268886268 Hi and Welcome Tramadol Warriors, Please come on in and make yourself comfy. All are welcome.
Avatar n tn You can't do that, however, if you're on other medications because it might flush them out more quickly than they can be absorbed. What the liver cleanse does is rid the body of any portions of the medication that were fat soluble and are still in your system, and flushes out toxins. What kind of cleanse to use is complicated; I'd feel better if you researched this some and saw a naturopath or holistic nutritionist than me recommending something.