I was on 100mg per day for 4 years, then have reduced it myself to 25mg a day. The
liver enzymes were still elevated
and and an ultrasound showed fatty liver disease. There is no scarring, and don't want there to be. The odd thing is that I tried a couple of generics and they went down. The generic did not do the job, so I switched back to name brand. I have gained 14 pounds in the 6-7 months I have been on the name brand Pristiq again, and the enzymes went up a bit.