625mg for 7 months and did very well. Before that, I had tried everything else
with very little improvement. Before
Premarin I was having hot flashes, anxiety, and terrible insomnia. After the first few days of taking Premarin, I began to notice great improvement. My hot flashes went away and insomnia disappeared. I had a few bumps along the way but then everything balanced out. Now, the old symptoms have returned with a vengeance. My doctor increased it to the next higher dosage of 0.