Hello,
Prednisolone has been used
in treatment of sinus infections.It can be used
in combination with methotrexate but only
in sinus pain due to wegener’s granulomatosis.It can not be used in allergic sinusitis due to its various adverse reactions.
Cyclophosphamide is the drug of choice along with prednisolone in wegener’s granulomatosis but methotrexate is used to maintain remission after a person has initially received cyclophosphamide.