Phenytoin use in pregnancy
Common Questions and Answers about Phenytoin use in pregnancy
dilantin
In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780]
Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.
I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment.. in both cases the treatment in Phenytoin and no known to me (till now a treatment to over count its side effects from gingival hypertrophy to the respiratory problems).
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
My dad who is 81 years old in India is on Citilin 500mg daily. The neurologist prescribed it after he had TIA number of times. He used to get seizures like symptoms and loose his consciousness. He was bedridden and stopped walking completely. Now, he is up on his feet and doing his regular work after regular physiotherapy.
At first, he had trigeminal neuralgia and he was on carbamezapine 150mg twice daily and then 300mg twice daily. I just need to know how long he has to be on Citilin.
Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm
Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body. Hence, every person react differently to same drug.
An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes. Whereas if you are a chronic alcoholic, the phenytoin levels may be lower than expected and can cause seizures. I suggest you consult with your neurologist in this regard. Hope this information helps. Take care.
Taking Dilantin in early pregnancy may lead to birth defects but they are relatively uncommon. The various defects which may occur are growth delay, limb abnormalities, facial defects; mental retardation etc. Inform your gynecologist about your delayed periods. Take up urine pregnancy test. If you are pregnant your doctor may gradually decrease the dose and stop it and may prescribe an alternative anti seizure medicine which is safe during pregnancy.
During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
This means that it is not known whether buprenorphine and naloxone will be harmful to an unborn baby. Use of buprenorphine and naloxone during pregnancy may cause withdrawal symptoms in a newborn baby. Do not take buprenorphine and naloxone if you are pregnant or could become pregnant during treatment.
Contrary to what you may have heard methadone is not safe during pregnancy, it is actually more dangerous to a baby than heroin. I am not sure why doctors prescribe it but they shouldn't.
I think the best person to ask this question to would be your pharmacist. They are typically very knowledgeable about how medications interact with one another. Normally, when you get you rscripts filled (so long as you're using the same pharmacy for all of them), their computers will automatically check for interactions, but if you're just doing research on the possible interactions (or use different pharmacies), just give them a call.
Sure enough, I had a full fledged grand mal for the first time in 18 years. My blood levels showed I was low (well below the desired 10 to 20). Can anyone tell me why the generic works different than the brand name? I've heard they use different bonding agents for the capsules as one possibility.
we have tried sleep medications in low dosages back in january. he only sleeps 2 - 3 hours per night, and right now im concerned more about his crying before falling asleep. i am at a loss as to what i can do to help him. its like he is crying in pain but went for physical last week and his pediatrician said after the exam it night be his medication or perhaps something happened to his brain during his last seizure. i was tempted to bring him to the er several times.
Hi,
Supplements are never really safe, they effect different people in different ways.
I have a Seizure Disorder, if I take Saint John's Wort, I'll be in trouble. Talking with my wife about your post, she reminded me that "Green Tea" cause both of us to experience a marked increase in PVCs.
My wife, a medical assistant, remarked that belladonna is "natural", yet a very deadly toxin.
A few weeks ago I woke up with yellow crust on the corner of my lips and it went away in 2 days, and today I woke up and it's in the exact same spot again except a little more then before. It doesn't hurt or itch, it feels like my lips are very very dry. I don't smoke, I have grandmal seizures and my medication is phenytoin and kepra but I didn't read anywhere that would be a side effect so I'm worried this could be a STD or something.
m on 20mg. Coincidence or not, we both contracted type II in recent years. I believe that the benefits pf statins outweigh the risks and have altered my eating lifestyle so to nearly exclude carbohydrates. This has enabled me to continue statin regime while keeping my fasting blood glucose levels at acceptaptable unmedicated levels. My wife on the other hand continues to take Metformin while on the statin drug.
s say the half life of Drug A is 5 hours and you have taken 10mg dose. In the next 5 hours, only 5mg of the drug will remain in the body. In another 5 hours only 2.5mg will remain and then 1.25mg and so on.
It takes about 4 -5 half lives for the drug to be completely metabolized. Hence in the case of Depakote, since the half life is 16 ± 3 hours (lets take a maximum of 19 hours), the time for complete metabolism will be 19 X 5 = 95 hours. That means 4 complete days.
Facial twitches are caused by stress and anxiety, muscle fatigue, side effects of medicines, high intake of caffeine, Parkinson’s disease in elderly, magnesium deficiency etc. Hemi facial spasm may be seen in tumors, multiple sclerosis, stroke etc. treatment may include balanced diet with mineral supplements like potassium, calcium, magnesium, massages for fatigue, B complex supplementation like avocadoes, bananas, legumes etc. drugs like gabapentin, phenytoin are used for hemifacial spasm.
but that was too high I was like a walking zombi, loosing my memory, nerves in hands and legs started to jump, slight quiver in hands, etc. It was awful. I was then lowered to 200mg which I could handle quite well. My levels were checked in Feb.08 and the levels were low at 29, my Dr. raised the dose to 250mg wich moved my levels to 55. which she said was good. In a short time of being on that I started to get the same side affects as on the 300mg. My Dr.
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