)
At high concentrations in vitro, clopidogrel inhibits P450 (C). Accordingly, Plavix may interfere with the metabolism of
phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin, and many non-steroidal anti-inflammatory agents, but there are no data with which to predict the magnitude of these interactions. Caution should be used when any of these drugs is co administered with Plavix.