Phenytoin metabolism

Common Questions and Answers about Phenytoin metabolism

dilantin

Avatar n tn Hi, is he on some other drugs too because other drugs might decrease the level of phenytoin by enhancing its metabolism via induction of enzymes and can lead to drug drug interction. “Drugs which may decrease phenytoin levels include: carbamazepine, chronic alcohol abuse, reserpine, and sucralfate. Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin.
Avatar n tn ) At high concentrations in vitro, clopidogrel inhibits P450 (C). Accordingly, Plavix may interfere with the metabolism of phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin, and many non-steroidal anti-inflammatory agents, but there are no data with which to predict the magnitude of these interactions. Caution should be used when any of these drugs is co administered with Plavix.
Avatar n tn Hi, drugs like phenytoin, carbamazepine, gabapentin, and pregabalin, tricyclic antidepressants like amitryptline and duloxetine are some of the alternatives. But every drug has got side effects, so it is more of hit and trial to find out the right medicine for right candidate. Individual’s body respond differently to different drugs depending upon their genetic make up and metabolism.
Avatar n tn Phenytoin may alter the metabolism of thyroid hormones, reducing its effect; there is limited documentation of this interaction, but monitoring should be considered. AR-10 I am on 100mcg Levothyroxine sodium. Thanks for the input...Talk with my doctor on Tuesday!
5268376 tn?1406179712 If a new drug is added, it has the potential to slow down this metabolism, sometimes resulting in greatly increased levels of the original drug or the newer drug.
Avatar n tn The estimates cited apply primarily to patients who are not taking drugs that affect hepatic metabolizing enzyme systems. For example, patients taking enzyme-inducing antiepileptic drugs (carbamazepine, phenytoin, and phenobarbital) will clear valproate more rapidly. Because of these changes in valproate clearance, monitoring of antiepileptic concentrations should be intensified whenever concomitant antiepileptics are introduced or withdrawn. ......
Avatar m tn In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780] Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.
Avatar f tn Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
Avatar n tn Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.
Avatar f tn Yet if I need to take an antibiotic I must avoid the mycin class. Mycins effect the metabolism of Phenytoin in the liver, slowing the elimination of it significantly. If I take a mycin class antibiotic, I may overdose on the amount of Phenytoin that I have been taking daily for years, simply based on this interaction. The Supplements you take may have similar effects on other supplements or medications. Be well.
1291453 tn?1272143404 You should tell your doctor if you experience any of these symptoms while taking phenytoin, so that your blood level of phenytoin can be measured and your dose reduced if necessary. " Also, he has had a major surgery, and will need time to recover. However, any changes need to be reported to the doctor.
Avatar n tn INR) may be ordered to assess the degree of blood-thinning when warfarin and clopidogrel are used together. The same enzyme also is responsible for the metabolism of phenytoin (Dilantin), tamoxifen (Nolvadex), tolbutamide (Orinase), torsemide (Demadex), and fluvastatin (Lescol). Although important interactions between clopidogrel and these drugs are unlikely, interactions should be looked for carefully.
Avatar n tn Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..
Avatar m tn Hello AB, welcome to the medhelp forum. Phenytoin can cause certain side effects like dizziness and mental confusion. Some people may also manifest incoordinate movements. Weight gain is not a documented side effect. It could be related to your alcohol consumption or wrong dietary habits and lack of exercise. An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes.
Avatar f tn During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
Avatar m tn Does anyone know if having your Gallbladder removed slows down your metabolism? or does it speed it up? What have you experienced?
Avatar f tn If you really want to kick-start your metabolism, you may also try dividing your meals up into smaller portions that you eat more often throughout the day. Every time you eat, it helps your metabolism rise, so as strange as it may sound, eating frequently can help you lose weight or maintain a healthy weight. Take care!
1203175 tn?1265553335 Anyone know how to kick start your metabolism so you start losing pounds, other than weight loss medications? Will not use those.
1397290 tn?1357777871 Calorie-intake should be according to your physical activity. 2800-3000 is quite a lot, which if you don't gain of it, you should perhaps seek professional aid.
Avatar f tn I totally forgot to tell you that he is on Phenytoin 100mg once daily. Can this be continued and taken for a long period of time? Thank you doctor once again for your immediate reply.
Avatar f tn Addition of other antiepileptic drugs like phenytoin,lamotrigene and sedatives will be helpful for controll of his night symptoms.
1936411 tn?1333831849 ve heard of that might help with the itch are trying the over the counter antihistamines or antihistamine hydroxyzine (Atarax), anticonvulsants (e.g. gabapentin, carbamazepine, phenytoin), antidepressants (e.g. amitriptyline, paroxetine, mirtazapine), and even Pregabelin (Lyrica)....
Avatar f tn A few weeks ago I woke up with yellow crust on the corner of my lips and it went away in 2 days, and today I woke up and it's in the exact same spot again except a little more then before. It doesn't hurt or itch, it feels like my lips are very very dry. I don't smoke, I have grandmal seizures and my medication is phenytoin and kepra but I didn't read anywhere that would be a side effect so I'm worried this could be a STD or something.