phenytoin macrocytic anemia

Based on my web search, if your results are indeed above range, this could be an indication of macrocytic anemia which indicates a vitamin B12 and/or folate deficiency. Here is a good link explaining it - https://www.healthline.com/health/macrocytic-anemia#types-and-causes. Let us know what more you find out.

Hello, Mean Corpuscular Hemoglobin (MCH) means how much hemoglobin is riding on the red blood cells. This happens in macrocytic anemia (macrocytic meaning large red blood cells, anemia meaning low levels of RBC). The Mean Platelet Volume tells us how big these platelets are; how uniform in size the platelets are.

The main reason that the MCH level would be too high is because of macrocytic anemia. Macrocytic anemia is a blood disorder in which not enough red blood cells are produced, but the ones that are present are large (thus fitting more hemoglobin). Macrocytic anemia is often caused by having too little vitamin B12 or folic acid (a type of vitamin) in the body.

An elevated MCH blood test result (high levels) indicates macrocytic anemia due to paucity of folic acid or vitamin B12 or thyroid problems. Alcoholism can also raise MCH levels.

Thanks for this rply,actually I have stopped all those addictions 7 years ago only,now from last 1 year I HV been suffering from psoriasis and a year back I had blood check up it showed that I HV macrocytic anaemia and mild thrombocytosis but as I was taking medication for my skin issues psoriasis I didn't care about those anemia and health ...Is that putting me in trouble I have not even taken medication for that macrocytic anamia .

Hi there, If you are suspecting that you are anemic then it is best to start taking foods rich in iron like meat, green leafy vegetables, pulses etc. People suffering from hypothyroidism are prone for developing macrocytic anemia. It is caused by inadequate nutrition and malabsorption of vitamin B12 and folic acid. It occurs because T3 and T4 hormones are involved in absorbing these nutrients. It is best to consult a doctor and discuss your concerns.

Low thyroid activity can lead to this because of a decrease in absorption of vitamin B12 and folic acid caused by a decrease in hydrochloric acid. For this, one must rule out the autoimmune condition below and if it is not autoimmune supplement with B12, folic acid and possibly hydrochloric acid. Pernicious anemia: This is an autoimmune disease caused by an autoimmune attack on intrinsic factor which is responsible for helping the body absorb vitamin B12.

Clumping happens if the sample is held too long before processing, gets too warm, etc. It means that the count is innacurate (can't count a big glob that's made of clumped together platelets) and the sample is worthless, always aggravating. Many of my sunmmertime platelet samples clumped because of long transport. Speaking of giant blood cells, my red blood cells always came out 'macrocytic' (big celled) on the lab report when I was on procrit.

The antiepileptic drugs need to be checked for a dosage modulation, assessment of adverse effects due to chronic usage over years like megaloblastic anemia, gingival hypertrophu and osteomalacia with phenytoin. Take care.

The MCV is elevated when your RBCs are larger than normal (macrocytic), for example in anemia caused by vitamin B12 deficiency. When the MCV is decreased, your RBCs are smaller than normal (microcytic) as is seen in iron deficiency anemia or thalassemias. MCHC: Mean Corpuscular Hemoglobin Concentration is a calculation of the average concentration of hemoglobin inside a red cell.

Other medications that increase the risk for anemia are certain antibiotics, some antiseizure medications (phenytoin), immunosuppressive drugs (methotrexate, azathioprine), antiarrhythmic drugs (procainamide, quinidine), and anti-clotting drugs (aspirin, warfarin, heparin).

In patients with anemia, it is the MCV measurement that allows classification as either a microcytic anemia (MCV below normal range), normocytic anemia (MCV within normal range) or macrocytic anemia (MCV above normal range). The mean corpuscular hemoglobin, or "mean cell hemoglobin" (MCH), is the average mass of hemoglobin per red blood cell in a sample of blood. It is reported as part of a standard complete blood count.

The main reason MCH level is high is due to macrocytic anaemia. Macrocytic anaemia is often caused by vitamin B12 or folic acid deficiency. Vitamin B12 deficiency causes extreme fatigue and either high or low cortisol levels. I had severe adrenal insufficiency due to severe vitamin B12 deficiency. Sounds like you need to start thyroid medication again too. That causes puffiness in the face and eyes and fatigue and stress on the adrenal glands. I have hypothyroidism as well just to add.

Anemia could most commonly be nutritional and macrocytic anemia is due to vitamin B12 and folic acid deficiency. Discuss these options with your doctor when you happen to meet him next time. In the meantime you could follow certain precautions. Avoid smoking and alcohol. Avoid drugs like paracetamol and sedatives. Get vaccinated for hepatitis A and B. Take a good protein diet. Hope this helped and do keep us posted.

Anemia in liver disease can be due to many causes. Macrocytic anemia could be due to lack of vitamin B12 or folic acid which could be due to nutritional causes. Low transferrin can be due to poor production of transferrin by the liver, due to liver disease or excessive loss of transferrin through the kidneys into the urine. Also, in liver disease there could be excessive bleeding leading to anemia. What was your hemoglobin level, this will indicate anemia.

A higher MCV can be seen in hemolytic anemia, pernicious anemia, vitamin B12 and/or folic acid deficiency, and in alcoholism. High MCH is due to large red cell or macrocytic anemia and occurs due to vitamin B12 and folate deficiency and due to liver disease. So, even though your B12 and folate levels are normal, they may actually be low and being managed by supplementation. The cause behind low vit B 12 needs to be found since you need to take its supplements to maintain normal blood levels.

Hi, deficiency of vitamin B 12 leads to defective synthesis of DNA which causes large sized red blood cells. “Megaloblastic anemia is an anemia (of macrocytic classification) which results from inhibition of DNA synthesis in red blood cell production. It is often due to deficiency of vitamin B12 and/or folic acid.

Nine patients with MS had serum vitamin B12 levels less than 147 pmol/L and, in the absence of anemia, this subgroup was significantly macrocytic and had significantly lower red blood cell folate levels than neurological and normal controls. Nine patients with MS had raised plasma unsaturated R-binder capacities, including three patients with very high values. There is a significant association between MS and disturbed vitamin B12 metabolism.

In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780] Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.

Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.

Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.

You should tell your doctor if you experience any of these symptoms while taking phenytoin, so that your blood level of phenytoin can be measured and your dose reduced if necessary. " Also, he has had a major surgery, and will need time to recover. However, any changes need to be reported to the doctor.

Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.

Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..

Hello AB, welcome to the medhelp forum. Phenytoin can cause certain side effects like dizziness and mental confusion. Some people may also manifest incoordinate movements. Weight gain is not a documented side effect. It could be related to your alcohol consumption or wrong dietary habits and lack of exercise. An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes.

my HbA1C is 6.0 and says s/b between 4.8 and 5.6 and ,\my RDW was18.2 and highest s/b 15.4 and all of my Lipid results were high and my carbon dioxide level was 17 and lowest s/b 18. Do any of these mean anything?

Phenytoin macrocytic anemia

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