phenytoin liver

In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780] Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.

I have a lot of liver funtions tests that keep coming back adnormal. Can taking really strong anitbotoics affect the liver. I have to take them becaause I have a biscupid Aortic valve..I got bit by a dog last last week. I cant have any infections going on to the valve.

Does prednisone effect dilantin and lamictal levels? I've been on dilantin and lamictal for over 5 years for seizures. I'm being tested for autoimmune hepatitis, I just had a liver biopsy. I don't want to take a chance on having a seizure.

Low blood levels of 25-hydroxyvitamin D may mean that you are not getting enough exposure to sunlight or enough dietary vitamin D to meet your body’s demand or that there is a problem with its absorption from the intestines. Occasionally, drugs used to treat seizures, particularly phenytoin (Dilantin), can interfere with the production of 25-hydroxyvitamin D in the liver. It can also be due to parathyroid gland problems. Very few foods in nature contain vitamin D.

Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.

Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.

t know how damaged your liver is I would recommend having a biopsy performed to find out how damaged your liver is by the hep c.

Antibiotics like tetracyclines, amiodarone, phenytoin are also known to cause black spots on skin. Apart from these conditions, suntan or sunburn can also cause formation of black spots on skin. Other health conditions like liver disease, hemochromatosis can also lead to this problem. to treat it i found a site here:http://www.buzzle.com/articles/black-spots-on-skin.

t understand is how the influence of a new drug can upset other medications you may be taking. Medications are metabolized, broken down, often by the liver or by the kidneys. If a new drug is added, it has the potential to slow down this metabolism, sometimes resulting in greatly increased levels of the original drug or the newer drug.

You should tell your doctor if you experience any of these symptoms while taking phenytoin, so that your blood level of phenytoin can be measured and your dose reduced if necessary. " Also, he has had a major surgery, and will need time to recover. However, any changes need to be reported to the doctor.

Milk thistle is an excellent to help to detox the liver and probiotics can help with gut issues. Also if you have a fatty liver (either due to alcohol or too much fructose from refined sugar/HFCS) you need to address this as well.

Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.

Diseases that Cause Elevated Liver Enzymes in the Blood The most common diseases causing abnormally elevated ALT and AST are acute viral hepatitis, such as hepatitis A or B, chronic viral hepatitis, such hepatitis B or C, cirrhosis of the liver (scarring of the liver due to long standing inflammation of the liver), liver damage from alcohol abuse or alcoholic fatty liver, hemochromatosis (a genetic condition causing long standing liver damage due to iron build up in the liver), and diminished

Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..

Hello AB, welcome to the medhelp forum. Phenytoin can cause certain side effects like dizziness and mental confusion. Some people may also manifest incoordinate movements. Weight gain is not a documented side effect. It could be related to your alcohol consumption or wrong dietary habits and lack of exercise. An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes.

I'm only 29 yrs. old and have been taking Dilantin since I was 15yr. old. My seizures have been under control the only time I actually had full blown seizures is when I was a teenager and I missed doses I had one and When my doctor decided to take me off my dilantin gradually since I hadn't had a seizure for 6 yrs. but, when I got completely off the medicine I had a full blown seizure from it.

Keep in mind that any disorder that destroys a large number of liver cells or disrupts the normal functioning of the liver cells can cause elevated bilirubin levels. Some of the causes of elevated bilirubin in adults are as follows:- Tumors affecting the gall bladder, liver or bile ducts could be responsible for elevated levels. An allergic reaction to the blood received during a transfusion can also cause the levels of bilirubin to rise in adults.

Gamma-glytamyl transpeptidase is an enzyme which is found in hepatocytes and biliary epithelial cells. GGT may be high in liver disease. In particular it is a feature of biliary outflow obstruction rather than hepatocellular damage. GGT (in men) = 11 - 50 i.u./l GGT (in women) = 7 - 32 i.u./l Note reference ranges may vary between laboratories. GGT serum measurement provides a very sensitive indicator of the presence or absence of hepatobiliary disease.

During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.

I totally forgot to tell you that he is on Phenytoin 100mg once daily. Can this be continued and taken for a long period of time? Thank you doctor once again for your immediate reply.

I am not sure how I could be pre diabetic considering I lift weights and do cardio six days a week along with eating healthy but my spleen and liver were enlarged based on physical examination. The thing is though that I have a lymph node in my neck that has been there for five months and it is firm and a little larger and there is a pea sized one that is firm above it which I told her about and she said it's normal.

An ALP test may be order alone or as part of a routine liver panel to screen for liver damage even if no symptoms are present. If results of the ALP test are high but other tests that are part of the liver panel, such as AST and ALT are not increased, then a GGT test may be ordered to help determine whether the source of the high ALP is a bone disorder or liver disease.

Phenytoin liver

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