Phenytoin hyponatremia

Common Questions and Answers about Phenytoin hyponatremia

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Avatar f tn "We also asked if he had any other patients showing similar symptoms after taking Gleevec but got no response. " Well, from the cited article "Electrolyte Disorders Induced by Antineoplastic Drugs", we have: "In cancer patients, hyponatremia has an overall prevalence up to 47% with mild, moderate and severe degrees accounting for 36, 10, and 1%" So while severe is rare, overall is not at all rare.
502219 tn?1311357910 I read a article recently referring to the fact that Patients with hyponatremia had a higher mortality rate and that UNOS was considering adding sodium levels to the MELD calculation. I also found a MELD calculator that includes sodium at the mayo clinic site http://www.mayoclinic.org/meld/mayomodel8.html My sodium level averages from 128 to 130 and the MELD-NA Calculator gives me a much higher MELD of 20. Are they thinking of changing the MELD calculation?
Avatar m tn In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780] Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.
Avatar f tn Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
Avatar n tn Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.
1291453 tn?1272143404 You should tell your doctor if you experience any of these symptoms while taking phenytoin, so that your blood level of phenytoin can be measured and your dose reduced if necessary. " Also, he has had a major surgery, and will need time to recover. However, any changes need to be reported to the doctor.
Avatar f tn Hyponatremia is a common electrolyte disorder defined as a serum sodium level of less than 135 mEq per L. Treatment is based on symptoms and underlying causes. In general, hyponatremia is treated with fluid restriction (in the setting of euvolemia), isotonic saline (in hypovolemia), and diuresis (in hypervolemia). For more information, see Figure 1 and Table 1 in the following article: https://www.aafp.org/afp/2015/0301/p299.
Avatar n tn Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.
Avatar n tn Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..
Avatar m tn Hello AB, welcome to the medhelp forum. Phenytoin can cause certain side effects like dizziness and mental confusion. Some people may also manifest incoordinate movements. Weight gain is not a documented side effect. It could be related to your alcohol consumption or wrong dietary habits and lack of exercise. An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes.
Avatar f tn If you have hyponatremia maybe. Did they do a blood test? How long did they say to eat more then average sodium?
Avatar f tn During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
1108262 tn?1273179266 The Trileptal also began causing a lowering of my blood sodium levels (hyponatremia), a rare side effect for the medication, but I used salt pills to offset this and had to- guess what?- go for regular blood tests. And then depression and anxiety worsened over time. I also began to have these weird twitches and movements I couldn't control, one so badly I ended up in an emergency room with a neurologist questioning if the Trileptal was causing the problem.
Avatar f tn I totally forgot to tell you that he is on Phenytoin 100mg once daily. Can this be continued and taken for a long period of time? Thank you doctor once again for your immediate reply.
Avatar n tn What would be a rough formula for calculating sodium excretion. This has to handle extreme results like acute hyponatremia and hypernatremia. What is the maximum excretion at which point the body is unable to keep up with consumption? This information will not be used for any actual medical purpose on any actual organism, inaccuracy is acceptable and even intended to keep the calculations simple.
Avatar f tn Addition of other antiepileptic drugs like phenytoin,lamotrigene and sedatives will be helpful for controll of his night symptoms.
1936411 tn?1333831849 ve heard of that might help with the itch are trying the over the counter antihistamines or antihistamine hydroxyzine (Atarax), anticonvulsants (e.g. gabapentin, carbamazepine, phenytoin), antidepressants (e.g. amitriptyline, paroxetine, mirtazapine), and even Pregabelin (Lyrica)....
Avatar f tn A few weeks ago I woke up with yellow crust on the corner of my lips and it went away in 2 days, and today I woke up and it's in the exact same spot again except a little more then before. It doesn't hurt or itch, it feels like my lips are very very dry. I don't smoke, I have grandmal seizures and my medication is phenytoin and kepra but I didn't read anywhere that would be a side effect so I'm worried this could be a STD or something.
Avatar f tn drugs like gabapentin, phenytoin are used for hemifacial spasm. Other options are botulinum injections and microvascular decompression surgery. Hope this helps. Take care.
Avatar m tn Hi, Drinking too much water can lead to a condition known as water intoxication and to hyponatremia. This is most commonly seen in infants under six months of age and sometimes in athletes. This also results when a dehydrated person drinks too much water without the accompanying electrolytes. Excess water outside the cells draws sodium from within the cells out to re-establish the necessary concentration. As more water accumulates, the serum sodium concentration drops , hence, hyponatremia.
Avatar m tn On August 23rd, 2014, he was diagnosed with Tonsillitis, Hypertension, Hyponatremia, Hypokalemia and Hypoxemia by one hospital.
Avatar m tn Hi everyone, I'm new to this community. My neurologist just informed me that Osteoporosis and shrinkage of the Cerebellum are very serious side effects for long term users of Dilantin. Does anyone know more about this? I've been taking 500mg of Dilantin for over 30 years since I was a teenager, and now I'm terribly worried. Not one of the neurologists had mentioned anything about this over the years, and now at 46, I've learned that I may have severe osteoporosis.
Avatar n tn consult a neurologist immediately, a balanced diet, foods high in potassium, calcium and magnesium, massages to relieve physical stress and fatigue, vitamin B complex rich foods,certain drugs like gabapentin, phenytoin,carbamazepine, botulinum toxin injections. Take care.