Phenytoin hypersensitivity syndrome

Common Questions and Answers about Phenytoin hypersensitivity syndrome

dilantin

Avatar m tn In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780] Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.
Avatar n tn Erythema multiforme is a type of hypersensitivity reaction that occurs in response to medications, infections, or illness. Medications associated with erythema multiforme include sulfonamides, penicillins, barbiturates, and phenytoin. Associated infections include herpes simplex and mycoplasma infections. The exact cause is unknown. The disorder is believed to involve damage to the blood vessels of the skin with subsequent damage to skin tissues. Are there other signs or symptoms present?
Avatar f tn I am pretty sure this is neurological. First, I have had restless legs syndrome since I was little. It has gotten worse as I have gotten older. I am 45 now. I can get it just in my legs or whole body. It isn't pain, just creepy crawly and I take meds. For awhile now, maybe over a period of 10 years, I have noticed that I am super hypersensitive to touch, especially my legs which can cause them to start "acting up".
Avatar f tn It was our experience that these patients have a characteristic symptom complex in association with their chronic cough which enables it to be categorised as a single syndrome. We have termed this the ‘‘Cough Hypersensitivity Syndrome.’’We proceeded to test this hypothesis by constructing a questionnaire that elicits the major components of this syndrome and subsequently testing its validity.
Avatar m tn Hi everyone, I'm new to this community. My neurologist just informed me that Osteoporosis and shrinkage of the Cerebellum are very serious side effects for long term users of Dilantin. Does anyone know more about this? I've been taking 500mg of Dilantin for over 30 years since I was a teenager, and now I'm terribly worried. Not one of the neurologists had mentioned anything about this over the years, and now at 46, I've learned that I may have severe osteoporosis.
Avatar n tn I have been on Coumadin for 18 years due to Lupus Anticoagulant (Antiphospholipid Syndrome) and several DVTs. In 2005 had MI with occlusion of the LAD artery and had drug stent inserted and I am still on plavix. My doc has debated when to take me off the Plavix safely....what are the recent studies about this dilemma? thanks so much!
Avatar n tn , I still have no definitive diagnosis, though a peripheral hyperexcitability syndrome (neuromyotonia, benign fasciculation syndrome, cramp fasciculation syndrome) is under consideration. But my healthcare provider lacks specialists for these, so I'm stuck at the moment. Neurontin did nothing for me. Neither did the standard tricyclic antidepressants used for various pain disorders. Anticonvulsant meds help to some degree, as do lifestyle changes. Good luck.
Avatar f tn Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
779627 tn?1235845890 I have been diagnosed with hypersensitivity pneumonitis. In 2004, I drove the length of US 95 from Maine to North Carolina. In southern Virginia, I stayed with friends in a cabin near the Great Dismal Swamp. Two days later, in Manhattan, we ate a late lunch near the WTC site. I ate my calamari. Both hands started to itch. Soon, both hands were covered with blood blisters. I had developed a fever. I was admitted to the Norwalk, CT hospital with a high fever.
Avatar n tn Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.
Avatar n tn I had a thalamic stroke December 7 and am now having pain and numbness and hypersensitivity on the affected side. This seems to shift and change day to day. What is the treatment, if any, and what is the chance this will go away over time?
1291453 tn?1272143404 You should tell your doctor if you experience any of these symptoms while taking phenytoin, so that your blood level of phenytoin can be measured and your dose reduced if necessary. " Also, he has had a major surgery, and will need time to recover. However, any changes need to be reported to the doctor.
Avatar m tn Polycystic ovary syndrome, abbreviated PCOS, (the most common)[4] Congenital adrenal hyperplasia, in turn mostly caused by 21-α hydroxylase deficiency Cushing's disease Tumors in the ovaries or adrenal gland (cancer) Certain medications Insulin resistance Stromal Hyperthecosis - in postmenopausal women Obesity: As there is peripheral conversion of androgens to estrogen in these patients, this is the same mechanism as polycystic ovary syndrome, PCOS.
Avatar n tn Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.
Avatar n tn Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..
Avatar m tn Hello AB, welcome to the medhelp forum. Phenytoin can cause certain side effects like dizziness and mental confusion. Some people may also manifest incoordinate movements. Weight gain is not a documented side effect. It could be related to your alcohol consumption or wrong dietary habits and lack of exercise. An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes.
Avatar f tn In the last few months I have begun to notice hypersensitivity including pain and temperature sensitivity in the skin on my legs. Sometimes one at a time, sometimes both and sometimes as far up as my buttocks, but never my feet. The slightest touch can be painful such as if there was a burn or a scratch or a rash - though none of these has ever been present. Also cool temperatures such as sitting on a toilet, or touching something cooler than body temperature can be excruciating.
Avatar f tn During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
Avatar n tn Easy Bruising Syndrome,though less common in your age group is one of the conditions(not-serious) is a likely diagnosis. However consult your doc right away.