Phenytoin hyperplasia
Common Questions and Answers about Phenytoin hyperplasia
dilantin
Taking the drug with food may reduce some symptoms, however, clinicians should keep in mind that oral administration with continuous nasogastric feedings can significantly impair phenytoin bioavailability. Gingival hyperplasia is a adverse reaction in children and young adults, especially during long-term therapy. Emphasis should be placed on good oral hygiene and gum massage. Cataracts have also been rarely reported after long-term therapy.
Adrenal gland problems like adrenal tumors, congenital adrenal hyperplasia, Addison’s disease or Cushing’s syndrome also result in excess hair. At times the hair follicles are very sensitive to androgens in blood. This results in excess hair. Disorders of endocrine glands like pituitary, thyroid too cause this problem. It could be due to the higher testosterone level. The other possibility is that you have excessive body hair or hypertrichosis.
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
Hi everyone,
I'm new to this community.
My neurologist just informed me that Osteoporosis and shrinkage of the Cerebellum are very serious side effects for long term users of Dilantin. Does anyone know more about this?
I've been taking 500mg of Dilantin for over 30 years since I was a teenager, and now I'm terribly worried. Not one of the neurologists had mentioned anything about this over the years, and now at 46, I've learned that I may have severe osteoporosis.
Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm
Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.
Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..
Hello AB, welcome to the medhelp forum. Phenytoin can cause certain side effects like dizziness and mental confusion. Some people may also manifest incoordinate movements. Weight gain is not a documented side effect. It could be related to your alcohol consumption or wrong dietary habits and lack of exercise. An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes.
hi,you need some monitoring of phenytoin(eptoin) blood levels as valparin causes increase in blood levels of eptoin,which is responsible for gingivial hyperplasia(gum swelling).
Valparin and topirol both are associated with mental problems.
For gum swelling,best is to either reduce the dose of eptoin and maintain oral hygiene(drugs like azithromycin,isotrentoin and surgical procedures are being used for treatment)
In your case,dose adjustment based on eptoin levels will help.
During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
Dear Madge - I am scheduled to see a breast surgeon tomorrow and hopefully will finally learn how we are going to proceed. Although I have taken histology, I could not give you a good answer to your question after all these years. I felt it was a term that I needed to relearn in case I see this on my pathology report. I retrieved this from the cancer.
Atypical hyperplasia is a precancerous condition that affects cells in the breast. Atypical hyperplasia describes an accumulation of abnormal cells in a breast duct (atypical ductal hyperplasia) or lobule (atypical lobular hyperplasia).
Atypical hyperplasia isn't cancer, but it can be a forerunner to the development of breast cancer.
The process begins when normal cell development and growth become disrupted, causing an overproduction of normal-looking cells (hyperplasia). Atypical hyperplasia occurs when the excess cells stack upon one another and begin to take on an abnormal appearance. The abnormal cells can continue to change in appearance and multiply, evolving into noninvasive (in situ) cancer, in which cancer cells remain confined to the area where they start growing.
Hi,
I have recently undergone a stereotactic biopsy and my pathology reports came back as being diagnosed with Fibrocystic disease, areas of adenosis, sclerosing adenosis, Focal Ductal Hyperplasia, Apocrine Metaplasia and Microcalcifications." Through my research, I keep finding the word "atypical" coming up when I type in "Focal Ductal Hyperplasia with Apocrine Metaplasia".
Many patients are wrongly identified as prostatic hyperplasia and chronic prostatitis. Although prostatic hyperplasia is very just like chronic prostatitis during the early stage, they may be two different diseases. What are the symptoms of prostatic hyperplasia and chronic prostatitis? How to distinguish between prostatic hyperplasia and chronic prostatitis?
I totally forgot to tell you that he is on Phenytoin 100mg once daily. Can this be continued and taken for a long period of time?
Thank you doctor once again for your immediate reply.
Results came back Focal atypical lobular hyperplasia. Referred to general surgeon who was not familiar with lobular hyperplasia. What are the treatment options for this lesion?
s been hyperplasia or one is high risk for hyperplasia because an ablated lining (endometrium) can mask hyperplasia and cancer.
Please do your research and advocate for yourself before deciding how to proceed. Hysterectomy is a major life (and anatomy) altering surgery. I wish you the best in getting proper treatment!
In addition to the information I already knew, the report indicated my chest area included a triangular mass of thymic tissue, consistent with thymic hyperplasia. I asked my doctor about it and he said it is common in children, but rae in adults my age ( I'm 50 ), and he said it ws nothing to worry about. Well....that is easier said than done. I'd like to know what is thymic hyperplasia, what causes it, and is it something to be concerned about ?
Is there any formal grading for a lump which has hyperplasia as the biopsy result?How will you draw the margin between usual hyperplasia and atypical hyperplasia in pathology?Please answer.
regards....
Yes I have seen mine. Simple hyperplasia. And a focal complex atypia hyperplasia. Very little. What did they told you, and what is the true ?
Atypical ductal hyperplasia, atypical columnar cell hyperplasia and lobular carcinoma in situ. Proliferative fibrocystic change with intraductal papilloma and calcifications. No definite ductal carcinoma in situ or invasive carcinoma identified. The atypia is scattered throughout this sepcimen and focally severe.
I go to the Oncologist in a couple of weeks. To tell you the truth, I feel I may be undertreated. Will the oncologist go with this lumpectomy or further surgery?
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