Phenytoin cyp

Common Questions and Answers about Phenytoin cyp

dilantin

Avatar n tn Any grapefruit causes the liver to stop producing CYP 450 super-enzymes. These are necesssary to metabolize many drugs. Thus, at a minimum the drug will have no effect. Twenty-four hours later, the drug is still in the blood (unmetabolized) and you take a second dose. At this time the CYP superenzymes again begin to be produced sand you end up with too much of the drug metabolized. One issue is "how much grapefruit is necessary to affect the liver?" A single grapefruit is enough.
Avatar m tn What you are talking about are the so-called superenzymes CYP 450 series, heme proteins and catalysts, produced in the liver. If you have been taking the combination together for a long time there is no risk of overdose. The problem with certain drugs is that they reduce the ability of the body to metabolize the drug, usually by oxidation but in some cases by reduction. This, initially the drug does not completely metabolize and has an extended half-life.
Avatar m tn In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780] Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.
Avatar f tn Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
Avatar n tn Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.
Avatar f tn CYP 3A4 (major) into inactive and active metabolite (30 times less active than telaprevir) Metabolic Inhibitor: CYP 3A4 - Substrate and inhibitor of P-gp (intestinal rather than systemic and would be saturable) Buprenorphine Metabolic Substrate: CYP 3A4>2C8 (norbuprenorphine active metabolite), UGT 1A1 and other UGT (norbuprenorphine combination and its metabolites) ===>>>Significance: Non clinically significant interaction. http://www.hivmedicationguide.com/details.asp?
1291453 tn?1272143404 You should tell your doctor if you experience any of these symptoms while taking phenytoin, so that your blood level of phenytoin can be measured and your dose reduced if necessary. " Also, he has had a major surgery, and will need time to recover. However, any changes need to be reported to the doctor.
Avatar n tn Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.
Avatar n tn Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..
Avatar m tn Hello AB, welcome to the medhelp forum. Phenytoin can cause certain side effects like dizziness and mental confusion. Some people may also manifest incoordinate movements. Weight gain is not a documented side effect. It could be related to your alcohol consumption or wrong dietary habits and lack of exercise. An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes.
2190999 tn?1504988891 The reason is that there is a universe of patients who are unable to metabolize tramadol. This is because of a variation in the cytochrome 450 (CYP 450) enzyme superfamily, particularly the isoform CYP2D6. These enzymes are responsible for enzymatic drug metabolism. For those with a genetic deficiency of this isoform tramadol does not work to relieve pain.
Avatar f tn During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
Avatar m tn Scientists know that some-thing in grapefruit inhibits an important enzyme, CYP 3A4, in the wall of the intestine. This enzymes critical for the breakdown of hundreds of medications. When its effectiveness is compromised, blood levels of such drugs can rise and trigger undesirable side effects. The responsible compound in grapefruit remains elusive.
3093770 tn?1389739126 Grapefruit has certain properties other citrus fruits do not happen to share: ___________________ The drug-grapefruit juice interaction is caused by inhibition of the intestinal cytochrome P-450 enzyme system, particularly cytochrome P450 3A4 (CYP450 3A4), by 1 or more of the components in grapefruit juice.
Avatar m tn A certain universe of patients exhibit a certain toxicity when exposed to lidocaine, as well as other drugs. I can't say for certain this is the case. Another possibility is lack of certain CYP 450 superenzymes in the liver necessary to metabolize certain drugs. Another possibility is contamination of the drug batch from the manufacturer due to failure to comply with ISO 9000 manufacturing protocols.
Avatar f tn I totally forgot to tell you that he is on Phenytoin 100mg once daily. Can this be continued and taken for a long period of time? Thank you doctor once again for your immediate reply.
Avatar m tn Mechanism of Injury The mechanism of liver injury from tadalafil is unknown, but it is metabolized in the liver via the cytochrome P450 system (CYP 3A4) and a toxic or immunogenic intermediate may account for the rare instances of hepatic injury linked to its use. Outcome and Management The liver injury linked to tadalafil has been self-limited and resolving within 2 to 3 months.
Avatar f tn Addition of other antiepileptic drugs like phenytoin,lamotrigene and sedatives will be helpful for controll of his night symptoms.
1936411 tn?1333831849 ve heard of that might help with the itch are trying the over the counter antihistamines or antihistamine hydroxyzine (Atarax), anticonvulsants (e.g. gabapentin, carbamazepine, phenytoin), antidepressants (e.g. amitriptyline, paroxetine, mirtazapine), and even Pregabelin (Lyrica)....
Avatar f tn A few weeks ago I woke up with yellow crust on the corner of my lips and it went away in 2 days, and today I woke up and it's in the exact same spot again except a little more then before. It doesn't hurt or itch, it feels like my lips are very very dry. I don't smoke, I have grandmal seizures and my medication is phenytoin and kepra but I didn't read anywhere that would be a side effect so I'm worried this could be a STD or something.
Avatar f tn drugs like gabapentin, phenytoin are used for hemifacial spasm. Other options are botulinum injections and microvascular decompression surgery. Hope this helps. Take care.
Avatar m tn Hi everyone, I'm new to this community. My neurologist just informed me that Osteoporosis and shrinkage of the Cerebellum are very serious side effects for long term users of Dilantin. Does anyone know more about this? I've been taking 500mg of Dilantin for over 30 years since I was a teenager, and now I'm terribly worried. Not one of the neurologists had mentioned anything about this over the years, and now at 46, I've learned that I may have severe osteoporosis.
Avatar n tn consult a neurologist immediately, a balanced diet, foods high in potassium, calcium and magnesium, massages to relieve physical stress and fatigue, vitamin B complex rich foods,certain drugs like gabapentin, phenytoin,carbamazepine, botulinum toxin injections. Take care.