phenytoin and skin rash

This reaction is generally confined to the extremities but can affect the trunk and face and may be irreversible. Severe dermatologic reactions to phenytoin are infrequent. Some evidence, however, suggests that erythema multiforme is more likely in patients who undergo radiation therapy while receiving phenytoin.[22] Lupus-like symptoms have been described for phenytoin. Whether phenytoin administration will exacerbate preexisting idiopathic systemic lupus erythematosus (SLE) is unclear.

Medications associated with erythema multiforme include sulfonamides, penicillins, barbiturates, and phenytoin. Associated infections include herpes simplex and mycoplasma infections. The exact cause is unknown. The disorder is believed to involve damage to the blood vessels of the skin with subsequent damage to skin tissues. Are there other signs or symptoms present? A skin lesion biopsy and microscopic examination may be helpful to differentiate erythema multiforme from other disorders.

Subsequent to discharge on 10 July, she was put on phenytoin 200 mg od. She broke out with fever again on 15 July and the fever lasted for about 4 days with daily temperature peaking in the afternoon (max 101 F). The face and body were covered with rash similar to measles which resolved by 20 July. Could she have had measles at her age? Why did she have convulsions? Could anyone throw any light on the episode.

You should tell your doctor if you experience any of these symptoms while taking phenytoin, so that your blood level of phenytoin can be measured and your dose reduced if necessary. " Also, he has had a major surgery, and will need time to recover. However, any changes need to be reported to the doctor.

It is less messy and preferably easy to use than the Selsun and Ketoconazole shampoos which needs to applied on the patches of affected skin after an evening bath, left to dry the whole night and washed off the next morning. For widespread or stubborn infections, itraconazole tablets have shown good results in curative aspects, but avoid its interaction with other drugs like antacids, astemizole, phenytoin and rifampicin.

During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.

Antibiotics like tetracyclines, amiodarone, phenytoin are also known to cause black spots on skin. Apart from these conditions, suntan or sunburn can also cause formation of black spots on skin. Other health conditions like liver disease, hemochromatosis can also lead to this problem. to treat it i found a site here:http://www.buzzle.com/articles/black-spots-on-skin.

Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.

Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.

Hi everyone, I'm new to this community. My neurologist just informed me that Osteoporosis and shrinkage of the Cerebellum are very serious side effects for long term users of Dilantin. Does anyone know more about this? I've been taking 500mg of Dilantin for over 30 years since I was a teenager, and now I'm terribly worried. Not one of the neurologists had mentioned anything about this over the years, and now at 46, I've learned that I may have severe osteoporosis.

Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.

Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..

Whereas if you are a chronic alcoholic, the phenytoin levels may be lower than expected and can cause seizures. I suggest you consult with your neurologist in this regard. Hope this information helps. Take care.

It could be a sinus infection. Do you have the symptoms of runny nose along with the sore throat? Even if you don't have rhinorrhea (runny nose) still could be sinus. Check the lymph node, if the swelling is less than an inch, then you needn't to see the doctor. See the skin colour above the lymph node, if the skin is red or pink, it means that the lymph node is loosing the battle against the infectious agent, you better get yourself checked then.

Pale skin areas are due to too little melanin or underactive melanocytes. Skin with too little melanin is called hypopigmented skin. Skin that has turned darker or lighter than normal is usually not a sign of a serious medical condition, unless the skin's texture is different or additional light spots continuously occur. If it is a concern, you'll need to visit a dermatologist. The physical exam will include: •When did the discoloration develop? •Did it develop suddenly?

I went thru this painful bleeding rash on my arms and legs for years..ugh its just awful. Went to every skin Dr and they were stumped..well I just had thyroid surgery to remmove toxic nodule and half my thyroid...guess what? The rash is finally clearing up all by it self now! Yaaaaay! Tell you Dr about it and insist you get your thyroid treated..myself I recomend the surgery over the radiation. A litter more painful but much safer esp for those of us with thyroid rash!

Drug interaction of Claravis or Accutane includes tetracyclines , vitamin A-type drugs, vitamin A, and drugs that cause bone loss such as anti-seizure drugs such as phenytoin and corticosteroids. If you experience severe headaches and other symptoms like mood changes, muscle /joint pain or painful swallowing or peeling skin, it is best that you inform your doctor for proper management. Also when prescription medicine for migraine is not providing relief. Take care and do keep us posted.

I would definitely pay attention to any rash. I have been on synthyroid for years and because of a comment I made to my doctor about feeling low on energy, we switch my regular medication routine to include cytomel. What a mistake - Within 3 days I noticed a rash, by day five it was causing sever grief in several areas of my body - the wrists, thighs and around my vagina. I have been miserable. Called doctor and 2 days ago took myself off cytomel.

If you are pregnant your doctor may gradually decrease the dose and stop it and may prescribe an alternative anti seizure medicine which is safe during pregnancy. Sudden withdrawal of antiseizure medication may precipitate seizures in a pregnant woman which can be dangerous for the fetus. Medicines are prescribed during pregnancy only if the benefits outweigh the risks. Your doctor may prescribe you high dose folic acid 4 mg to prevent spinal cord deformities. I sincerely hope it helps.

I have been on Coumadin for 18 years due to Lupus Anticoagulant (Antiphospholipid Syndrome) and several DVTs. In 2005 had MI with occlusion of the LAD artery and had drug stent inserted and I am still on plavix. My doc has debated when to take me off the Plavix safely....what are the recent studies about this dilemma? thanks so much!

The only antibiotic that has ever been shown to interfere with birth control levels and effectiveness is a medicine called rifampin which is used to treat tuberculosis. Rifampin may also interfere with the birth control patch and vaginal ring so if you are taking it, be sure to use a back-up, non-hormonal (i.e. condom) form of birth control.

I came back and started developing this rash and a pain that almsot seemed internal where the rash is, I went to my doctor who said it was fungal and prescirbed ketzancole and applied it for two weeks with no results. He then prescirbed cortisone for two weeks and again no results. I was tested for std's 10 days after I got back. I came back april 16 and was tested on april 25. All tests came back negative.

Everytime I get an itch and I scratch, it burns terribly bad especially my legs and arms. Has anyone experienced this?

When I was trying to it on rash the whole thing opend up and spilled on my hands. 2 days later my skin on my palms and fingers started to peel very badly which lasted about 3 weeks. Do you guys know if the peeling might have caused by Cortizone.10?

I can still tell where the rash is as the skin is still red. Another symptom I have is that my skin appears to be more red than normal, mostly on my hands and knees. The surface of my skin is fine, it just seems that there is an increase in blood in these areas. When I press down on my skin for a few seconds and then lift up, my skin is white for a few seconds and then turns back to red. I noticed this symptom about a week after the encounter.

She cannot tolerate any kind of creams that have been prescribed, even the .05%. Her rash is on her face and neck. Her hygiene is maintained with mainly water and glycerin, nothing harsh at all. She cannot be in the sun, wind, etc. Is there a particular reason that she should see a gynecologist??

I totally forgot to tell you that he is on Phenytoin 100mg once daily. Can this be continued and taken for a long period of time? Thank you doctor once again for your immediate reply.

Surprisingly, much of the literature has focused on the effects of anticonvulsant therapy on intrinsic thyroid function rather than the converse. Such medications as carbamazepine and phenytoin have been shown to displace thyroxine from plasma protein-binding sites and potentially increase its clearance. Free thyroxine (T4) and triiodothyronine (T3) will be increased, while serum T4 and T3 levels will be decreased.

Phenytoin and skin rash

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