Phenytoin and osteoporosis

Common Questions and Answers about Phenytoin and osteoporosis

dilantin

Avatar m tn Hi everyone, I'm new to this community. My neurologist just informed me that Osteoporosis and shrinkage of the Cerebellum are very serious side effects for long term users of Dilantin. Does anyone know more about this? I've been taking 500mg of Dilantin for over 30 years since I was a teenager, and now I'm terribly worried. Not one of the neurologists had mentioned anything about this over the years, and now at 46, I've learned that I may have severe osteoporosis.
Avatar f tn During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
Avatar m tn This reaction is generally confined to the extremities but can affect the trunk and face and may be irreversible. Severe dermatologic reactions to phenytoin are infrequent. Some evidence, however, suggests that erythema multiforme is more likely in patients who undergo radiation therapy while receiving phenytoin.[22] Lupus-like symptoms have been described for phenytoin. Whether phenytoin administration will exacerbate preexisting idiopathic systemic lupus erythematosus (SLE) is unclear.
Avatar f tn Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
Avatar n tn Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.
1291453 tn?1272143404 You should tell your doctor if you experience any of these symptoms while taking phenytoin, so that your blood level of phenytoin can be measured and your dose reduced if necessary. " Also, he has had a major surgery, and will need time to recover. However, any changes need to be reported to the doctor.
Avatar n tn Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.
605893 tn?1220181685 Osteoporosis is most common in women after menopause, when it is called postmenopausal osteoporosis, but may also develop in men, and may occur in anyone in the presence of particular hormonal disorders and other chronic diseases or as a result of medications, specifically glucocorticoids, when the disease is called steroid- or glucocorticoid-induced osteoporosis.
Avatar m tn Osteoporosis is a common condition where the bone becomes thin and fragile, creating an increased risk of fracture. Osteoporosis is usually painless until a fraction takes place, and osteoporosis is a major contributing factor to bone fracture, including hip fractures, which are more common as people age. There are almost 2 million hip fractures annually around the world. While in the U.S.
Avatar n tn Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..
Avatar m tn Whereas if you are a chronic alcoholic, the phenytoin levels may be lower than expected and can cause seizures. I suggest you consult with your neurologist in this regard. Hope this information helps. Take care.
109530 tn?1279743796 Also, other autoimmune diseases (celiac disease) cause malabsorbtion and therefore can contribute to osteoporosis. Many people have multiple autoimmune diseases. HTH.
Avatar f tn If you are pregnant your doctor may gradually decrease the dose and stop it and may prescribe an alternative anti seizure medicine which is safe during pregnancy. Sudden withdrawal of antiseizure medication may precipitate seizures in a pregnant woman which can be dangerous for the fetus. Medicines are prescribed during pregnancy only if the benefits outweigh the risks. Your doctor may prescribe you high dose folic acid 4 mg to prevent spinal cord deformities. I sincerely hope it helps.
7469840 tn?1409845836 I just googled ribavirin and osteoporosis, and there does seem to some connection, so will try to print out some articles for new doc, and will take all my hcv tx info with me too.
Avatar n tn I have been on Coumadin for 18 years due to Lupus Anticoagulant (Antiphospholipid Syndrome) and several DVTs. In 2005 had MI with occlusion of the LAD artery and had drug stent inserted and I am still on plavix. My doc has debated when to take me off the Plavix safely....what are the recent studies about this dilemma? thanks so much!
Avatar m tn I take Synthroid for hypothyroidism, and I was diagnosed with osteoporosis, I have tried several times to take calcium supplements within the guidelines when taking Synthroid, (more than 4 hours before or after taking med), and I become almost immediately exhausted, and sleep for 8-12 hours. I take only about 250 mgs of calcium, and vitamin D as well.
Avatar m tn Subsequent to discharge on 10 July, she was put on phenytoin 200 mg od. She broke out with fever again on 15 July and the fever lasted for about 4 days with daily temperature peaking in the afternoon (max 101 F). The face and body were covered with rash similar to measles which resolved by 20 July. Could she have had measles at her age? Why did she have convulsions? Could anyone throw any light on the episode.
231441 tn?1333892766 My TSH is now and has been for some time, at 0.01, my FT's are now slightly < mid range; and my doctors keep saying that it's going to cause osteoporosis; however, I've done some research and found that not to be true. In fact, I just posted for information about that a week or so ago and was given a couple of good sites. Here's the post: http://www.medhelp.
Avatar f tn My doctor told me that I have Osteoporosis and wants me to try Forteo an injection for two years. Has anyone tried this drug and what were your side effects, if any. I don't want to make my stomach problems worse than there already are.
Avatar n tn I have started mega doses of supplements and calcium and D and excercise and I want someone to tell me that that has worked for them. Most comments I get is to take the drug because it's more effective. I can't believe everyone is taking bisphosphonates or other drugs like that. Please let me hear from you if you see this!,,, Thanks, and hope you are doing well!
Nicelady I just had my frist Bone scan and the office called me and said I had osteoporosis and that they called in RX for Atelvia.. I picked up the RX and was reading the information and I am concerned about the side effect of this medication. Is this the only way to help with osteoporosis? Is there anything elso another way?
Avatar f tn Osteoporosis is the thinning of bone tissue and loss of bone density over time. If you do not get enough calcium, or if your body does not absorb enough calcium from the diet, bone production and bone tissues may suffer. As you age, calcium and phosphate may be reabsorbed back into the body from the bones, which makes the bone tissue weaker. And this happens with the bones of your entire body.
Avatar n tn I expect she is Anxious about it all aswell does she get out and is she as busy as she can be as she has a lot of pain ,it could make her feel very fedup, and that makes it worse.Does she have exercises to do for the Osteoporosis, I think they reccomend some to strenghthen her . There are a few books on the Market she can read .I hope you both do better soon, sounds like she needs some answers and she needs to demand them.
Avatar f tn Hello Dear, Connective tissue diseases are chronic inflammatory autoimmune disorders which can affect all connective tissues, i.e. joints, skin, muscles and blood vessels, and therefore have multiple effects on many different organs throughout the body. Although the commonest one is rheumatoid arthritis. Osteoporesis is not a connective tissue disorder,it may accompany a connective tissue disor Refer http://www.arc.org.uk/arthinfo/medpubs/6529/6529.aspder.
Avatar f tn Hello Dear, Connective tissue diseases are chronic inflammatory autoimmune disorders which can affect all connective tissues, i.e. joints, skin, muscles and blood vessels, and therefore have multiple effects on many different organs throughout the body. Although the commonest one is rheumatoid arthritis. Osteoporesis is not a connective tissue disorder,it may accompany a connective tissue disor Refer http://www.arc.org.uk/arthinfo/medpubs/6529/6529.aspder.
Avatar f tn I totally forgot to tell you that he is on Phenytoin 100mg once daily. Can this be continued and taken for a long period of time? Thank you doctor once again for your immediate reply.
Avatar f tn 0 and TT4 around 4.5). Each SAT occurance, my iodine uptake was initially zero and TPO and thyroglobulin antibodies negative. I was diagnosed with osteoporosis 2 years ago with Dexascan results having Z-scores slightly below -2.5. Recently I have been experiencing vague symptoms (fatigue, dry skin and hair, brain fog, etc.) that I attributed to recent menopause but my thyroid tests revealed the following: TSH = 4.24 (0.34-5.60) FT4 = 0.64 (0.62-1.12) TT4 = 3.9 (4.5-12.
1485696 tn?1312405527 My doctor had a bone density scan done and it showed early signs of osteopenia, not unusual for my age and for being postmenepausal. One year later, I was diagnosed with MS. Started on Copaxon, and seem to be keeping it at bay. Now, at 52, I suffered a pathological fracture of my sacrum, lifting a patient during my occupation as a paramedic. I should also mention that I have grade B spondilitis in my back at L5 and S1.
1650006 tn?1333909714 Hi im 29 and was diagnosed with Osteoporosis in the spine when i was 27, also have the mild form in my hips as well. Well i've just found out (after going through fertillity treatments) that i am 4 weeks pregnant. Im starting to worry about how my back will cope with carring a child, I've had a painfull back since way before the diagnosis, constently need regular physio to reduce the knots in my lower back/pelvis area.