Peginterferon alfa 2a roche

Common Questions and Answers about Peginterferon alfa 2a roche

pegasys

Avatar f tn These results are similar to those seen with the 48-week treatment regimen of VICTRELIS added to peginterferon alfa-2b and ribavirin in HCV RESPOND-2, a pivotal Phase III study. Taken together, these studies showed that VICTRELIS combined with either peginterferon alfa-2a or alfa-2b and ribavirin achieved significantly higher SVR rates in chronic HCV genotype 1 patients who failed prior therapy compared to peginterferon and ribavirin alone.
476246 tn?1418870914 Most patients who did not tolerate peginterferon alfa-2b/ribavirin due to AEs and who completed the full 36-week course of peginterferon alfa-2a/ribavirin treatment achieved SVR.
Avatar f tn These meds are through Roche. Pegasys (peginterferon alfa-2a) and Copegus (ribavirin) which is Roche and Pegintron (peginterferon alfa-2b) and Rebetol (ribavirin) which is Schering-Plough. Both are considered the current SOC.
Avatar m tn @VeteranB- Pegasys is brand name of peginterferon alfa-2a in india by Roche brand.
476246 tn?1418870914 26June2008 Roche announced today that the European Commission has approved a shortened, 16-week course of treatment with Pegasys (peginterferon alfa-2a (40 KD)) plus Copegus (ribavirin) for certain hepatitis C patients.
Avatar n tn Pegasys is a brand name for Peginterferon alfa-2a or Pegylated interferon alfa-2a which is an antiviral drug made by La Roche. It is given by injection. It is used in combination with another medication called Ribavirin (a pill), and a third medication, either Victrellis or Incivek, which are both pills, to treat Hepatitis C. Let us know if you have further questions.
Avatar m tn [24] Therefore, it is the recommendation of this author to reduce ribavirin stepwise by 200 mg every 2-4 weeks until adverse events either resolve or are tolerable. Peginterferon alfa-2a can be reduced from 180 to 135 µg/week and peginterferon alfa-2b from 1.5 to 1.0 µg/kg/week. Neither peginterferon alfa nor ribavirin dosing should be interrupted unless the adverse event is particularly severe and there is a concern for patient safety.
148588 tn?1465778809 12 weeks of telaprevir plus peginterferon alfa-2a/ribavirin followed by another 12 weeks of peginterferon alfa-2a/ribavirin (T12/PR24); 24 weeks of telaprevir plus peginterferon alfa-2a/ribavirin followed by an additional 24 weeks of peginterferon alfa-2a/ribavirin (T24/PR48); 24 weeks of telaprevir plus peginterferon alfa-2a and no ribavirin (T24/P24); or 48 weeks of peginterferon alfa-2a/ribavirin (the control arm) (PR48).
1375580 tn?1278739099 I think alfa-2a and alfa-2b are comparable for results as far as SVR goes. I also think that alfa-2a is sometimes better tolerated and has become the defacto standard. Maybe someone who has treated with alfa-2b can offer more information. I treated with alfa-2a and had the usual side effects, maybe a little worse than many since I had a long TX period, but it beats progression of liver disease by a long shot.
Avatar f tn A total of 1050 previous nonresponders to peginterferon alfa/ribavirin were randomized to long-term therapy with low-dose peginterferon alfa-2a (90 µg/week) or no treatment. Primary outcomes assessed at 3.5 years included death, hepatic decompensation, the development of hepatocellular carcinoma, and histologic fibrosis progression in patients who were noncirrhotic at baseline.
137025 tn?1217764741 Combination Telaprevir, Peginterferon alfa-2a, and Ribavirin Therapy Has Rapid and Sustained Antiviral Activity in HCV Genotype 1 Patients Posting Date: April 25, 2008 Randomized, placebo-controlled phase II study (PROVE 1) Summary of Key Conclusions * 12 weeks of telaprevir combined with 24 or 48 weeks of peginterferon alfa-2a and ribavirin produces significantly higher sustained virologic response (SVR) rates compared with 48-weeks of peginterferon alfa-2a and ribavirin in patients with ge
4920683 tn?1370195521 Two kinds of pegylated interferons are available -- peginterferon alfa-2a (also called alfa-2a) and peginterferon alfa-2b (also called alfa-2b). The main difference between these two pegylated interferons is in the dosing. Alfa-2a is used as a fixed weekly dose. Alfa-2b is used as a weekly dose based on the weight of the patient. There are other differences between the two drugs, but they are mostly technical and are used by the prescribing physician.
Avatar m tn Taken together, since the publication of the pivotal phase 3 trials for peginterferon alfa-2a and alfa-2b in combination with ribavirin, it took another 8 years to characterize the pharmacodynamic differences between the 2 drugs in detail," Zeuzem wrote.
Avatar m tn Lamivudine for 52 weeks versus placebo increased HBeAg loss at 16 weeks off therapy. HBeAg loss at 24 weeks post treatment was greater after peginterferon alfa-2a versus lamivudine. HBeAg seroconversion was assessed in 36 studies. Lamivudine or adefovir increased HBeAg seroconversion versus placebo. Interferon alfa-2b64,83 increased post-treatment seroconversion. Lamivudine monotherapy failed to sustain seroconversion.
511080 tn?1211208992 The medications currently approved by the US Food and Drug Administration (FDA) for the initial treatment of chronic hepatitis B include interferon alfa-2b, peginterferon alfa-2a, and the oral nucleoside/nucleotide analogs lamivudine, adefovir dipivoxil, entecavir, and telbivudine, with tenofovir under FDA review for likely approval in 2008. Each of these drugs has a number of advantages and disadvantages.
694630 tn?1227710675 today announced that Albuferon(R) (albinterferon alfa-2b) met its primary endpoint of non-inferiority to peginterferon alfa-2a (Pegasys) in ACHIEVE 2/3, a Phase 3 clinical trial of Albuferon in combination with ribavirin in treatment-naive patients with genotypes 2 and 3 chronic hepatitis C (p=0.0086). Albinterferon alfa-2b is being developed by HGS and Novartis under an exclusive worldwide co-development and commercialization agreement entered into in June 2006.
Avatar n tn I want to know if there are any clinical comparative studies on the efficacy and potency between Peg IFN Alfa 2a (pegasys) and peg IFN Alfa 2b (pegintron). I am about to begin the treatment to get rid of the virus and i am doing more readings and research into this one. I weigh 103 kg 30 yrs old. got a 10million viral load. your help is highly appreciated. Thank you.
Avatar m tn Thirteen patients with HBeAg-negative CHB received peginterferon alfa-2a (180 microg/week) for 60 wk or peginterferon alfa-2a (180 microg/week) for 12 wk followed by 48 wk of peginterferon alfa-2a plus lamivudine.
Avatar m tn Ocular side effects associated with oral ribavirin in combination with peginterferon alfa-2a, peginterferon alfa-2b, or interferon alfa-2b have included blurred vision (up to 6%). Corneal ulcer has been reported in less than 1% of patients treated with peginterferon alfa-2a alone or in combination with ribavirin tablets. Conjunctivitis (up to 5%) has been reported with ribavirin capsules/oral solution in combination with peginterferon alfa-2b or interferon alfa-2b.
Avatar f tn i am hbsag positive. where do i can find interferon alfa-2a and peginterferon alfa-2a?
Avatar m tn Selection of Weight-Based Peginterferon alfa-2b or Fixed-Dose Peginterferon alfa-2a Large clinical trials suggest that in genotype 1 HCV–infected patients treated with peginterferon alfa-2a or alfa-2b plus ribavirin (at variable dosing), SVR rates range between 42% and 46%. However, differences in study design, treatment regimens, and patient populations preclude comparison of the data across these trials.
Avatar f tn 1 ratio to one of two INCIVEK combination treatment groups (with and without a Peg-IFN-alfa-2a/RBV lead-in) or a control group. The T12/PR48 group received INCIVEK and Peg-IFN-alfa-2a/RBV for 12 weeks (without a lead-in), followed by placebo and Peg-IFN-alfa-2a/RBV for 4 weeks, followed by Peg-IFN-alfa-2a/RBV for 32 weeks.
541844 tn?1244309824 good luck Early virologic response after peginterferon alpha-2a plus ribavirin or peginterferon alpha-2b plus ribavirin treatment in patients with chronic hepatitis C. Di Bisceglie AM, Ghalib RH, Hamzeh FM, Rustgi VK. Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO 63110, USA.
Avatar m tn Direct hyperbilirubinemia was also more frequent with peginterferon lambda vs peginterferon alfa-2a. Indeed, 4 patients discontinued peginterferon lambda as a result of elevated bilirubin vs 0 patients receiving peginterferon alfa-2a. After discontinuing or reducing the dose of peginterferon lambda, bilirubin levels decreased rapidly.
168246 tn?1212063254 Peginterferon alfa-2a can be reduced from 180 to 135 µg/week and peginterferon alfa-2b from 1.5 to 1.0 µg/kg/week. Neither peginterferon alfa nor ribavirin dosing should be interrupted unless the adverse event is particularly severe and there is a concern for patient safety. Whenever the doses of peginterferon alfa and ribavirin are modified or temporarily interrupted, HCV RNA testing should be performed again to ensure that breakthrough has not occurred." 15.