Pegasys rbv

Common Questions and Answers about Pegasys rbv

pegasys

Avatar m tn - Willy ---------------------------------------- More than 80% of Hepatitis C Patients Treated in Study C208 Achieved an SVR with Telaprevir-Based Regimens * 83% SVR achieved with twice-daily regimen of telaprevir dosed with PEGASYS and ribavirin * Results highlight the use of response-guided therapy in managing treatment outcomes * Similar safety and tolerability observed between telaprevir-based regimens dosed either twice daily or three times daily BOSTON, Oct 31, 2009 (BUSINES
1476285 tn?1287337784 A detailed analysis of the relationship between body weight and SVR has suggested that the dose per kilogram is the determining factor of response in genotype 1 patients, based on the 40% to 50% rise in SVR for a 12-16-mg/kg increase in RBV dose (23). RBV dose by weight may impact its concentration in plasma, which also correlates with the response. Although this relationship has been well documented in genotype 1 patients, the data are less clear for other genotypes.
Avatar n tn A sustained virological response (SVR) of 70–80% is observed when either of these protease inhibitors is utilized with pegylated interferon (PEG-IFN) and ribavirin (RBV) in treatment naïve patients. Both agents are also highly effective in patients who failed to achieve a SVR during previous treatment with PEG-IFN/RBV. A rapid virological response (RVR) is observed in 56–60% of treatment naïve patients.
Avatar f tn Previously Treated Adults Study C216 (REALIZE) Study C216 was a randomized, double-blind, placebo-controlled, trial conducted in subjects who did not achieve SVR with prior treatment with Peg-IFNalfa- 2a/RBV or Peg-IFN-alfa-2b/RBV.
1961140 tn?1450738712 Hello All, Null responder to Pegasys/RBV in 2009. I am on disability, and pay for medicare Part D administered through Blue Cross. So, I have "Rx insurance"- great. My co pays per month for Pegasys/RBV would be $125 for 48 weeks, and $5K per month for the three months of Incevek. That is AFTER spending enough to fall into the "Catastrophic Coverage" designation. So the three drug regimen for 48 weeks would cost over $20K.
Avatar f tn There are no data to help guide substitution of one for the other HCV PI. If a patient has a serious adverse reaction related to PegIFN and/or RBV, the PegIFN and/or RBV dose should be reduced or discontinued. If either PegIFN and/or RBV are discontinued, the HCV PI should be stopped. https://www.aasld.org/practiceguidelines/Documents/2011UpdateGenotype1HCVbyAASLD24641.
Avatar m tn Hi, I'm expecting to begin tx in about a month. I'm stage 3/6, genotype 1a, vl around 1.5 million. I'm also HIV positive which is under control with meds (CD4 550-600, vl 101). I know this somewhat reduces my odds for achieving SVR, can anyone tell me whether coinfection is likely to have any effect on the severity of the side effects? I know I'll be taking 180 mg Pegasys, I don't know how much riba I'll be getting yet.
5045042 tn?1365890100 2 Anemia and Hemoglobin Analyses In Phase 2-3 studies, anemia was managed with RBV dose reductions in accordance with approved RBV labeling. If RBV was permanently discontinued for anemia, telaprevir/placebo had to be permanently discontinued as well. Erythropoiesis-stimulating agents (ESAs) were prohibited from most studies, and their use was reported in only 1.0% and 0.
Avatar f tn However, neither anemia nor RBV dose reduction adversely affected the SVR rate. Of note is that in the BOC trial, SVR rates in patients managed by RBV dose reduction alone were comparable to those in patients managed with erythropoietin therapy.23 Similarly, in the TVR trials, dose reduction of RBV had no effect on SVR rates, and therefore dose reduction should be the initial response to management of anemia.
Avatar f tn They told me that I could do the Pegasys/Ribavirin and be cured by July or to wait until August for when the new treatment is approved by my health insurance and be cured by October (by the way, I have genotype 2a). Me, being the type of person whom likes to take care of things immediately decided on the older treatment. I'm currently waiting on the call so they can FedEx me the medications.
Avatar f tn Retreatment of these patients with another course of PEG IFN plus RBV after they have not responded to an initial course of PEG IFN plus RBV is of marginal benefit. " all were on 2b for round 1 and 2a for round 2 confirming once again that that's not one of the variables worth varying.
Avatar f tn I am genotype 1a and started treatment with ribasphere, pegasys, and incevik in Sept. My starting VL was 127,000. My 4 week was undetectable. At 16 weeks, my VL was back up to 580. 20 weeks was down at 129. Then 24 weeks was 64. My dr is wantin to continue the pegasys and RIBA through 48 weeks. My concern is protocol says to stop if you are detectable at 24 weeks. My dr is a gastrointerologist. I guess my question is do I continue with treatment or get a new dr?
Avatar m tn 1) and treated for 48 weeks with PEG2b 1.5µg/kg/week or PEG2b 1.0µg/kg/wk + RBV 800-1400mg/day, or PEG2a 180µg/wk + RBV 1000-1200mg/day. Patients with virologic failure at treatment weeks 12 or 24 stopped therapy. Anemia was defined as Hb <10 g/dL. Anemic patients underwent protocol-defined RBV dose reduction after which EPO was permitted at investigator discretion. Viral response rates (ITT) were assessed in 3 groups: 1) No anemia; 2) Anemia/No EPO; 3)Anemia/EPO.
317787 tn?1473358451 The first time (2008) was a trial with Roche 1626 polymerase inhibitor, Pegasys and Ribavarin. I was UND between 7 or 8 weeks, relapsed 6 weeks after being pulled from tx at 43 of 48 weeks as the trial drug was too harsh on my system. Back then they refused to give me rescue drugs so I had no choice. I have diabetes which may have contributed to my relapse, during tx my sugar was so low I stopped checking it, DUH!
Avatar f tn i am currently into my 6th week of treatment w pegasys and copegus and my dr wants 2 add victrella as soon as he can get my insurance 2 approve. i was wondering if any1 has already started their treatment w victrella as well as the pegasys and copegus so i may get a bit of insight as 2 what i may expect if they do approve me.
Avatar f tn In the four trials, sofosbuvir was administered to nearly 1,000 patients with chronic HCV infection as part of an all-oral 12-week or 16-week treatment regimen in combination with ribavirin (RBV) in genotypes 2 and 3, or with RBV and pegylated interferon (peg-IFN) for 12 weeks in genotypes 1, 4, 5 and 6. Overall SVR12 rates (sustained viral response 12 weeks after completing therapy) from 50 to 90 percent were observed. Patients who achieve SVR12 are considered cured of their HCV infection.
223152 tn?1346978371 According to both bodies, the approved dosing regimen includes a 4-week lead-in phase with pegIFN/RBV, followed by boceprevir 800 mg 3 times daily with pegIFN/RBV for 32 weeks. The FDA recommends that for early responders (undetectable HCV RNA at Week 8 and maintained through Week 24), treatment then concludes at Week 36, but late responders (detectable HCV RNA at Week 8 but undetectable at Week 24) should receive an additional 12 weeks of pegIFN/RBV, ending treatment at Week 48.
Avatar n tn I am on triple therapy with Incivek, just did shot #10. Genotype 1, prior 3x non responder. I have looked for some stats on my chance for SVR and haven't really found anything...Pegasys and Riba have both been reduced because platelets dropped to 19. As of last week, platelets are up to 31, Pegasys was increased from 90 to 135, however, I remain on 800 Riba. Beginning PCR 1.