I think you'll find that a lot of people have irritation at the injection site. There were a few things that we found to be very helpful, and which reduced the redness at the site post-injection. One, make sure you've warmed up the Pegasys between your hands before, you don't want to inject cold interferon. Also, massaging the area for a few minutes post-injection was very helpful. Once we started doing these two things, the redness went away for the most part.