Pegasys half life

Common Questions and Answers about Pegasys half life

pegasys

1084115 tn?1385228589 The mean half-life for multiple doses in the body is about 12 days, but very long-term kinetics are dominated by the kinetics of RBCs (half-life 40 days). RBCs store ribavirin for the lifetime of the cells, releasing it into the body's systems when old cells are degraded in the spleen.
317787 tn?1473358451 The PEG (polyethylene glycol) protects the molecule from proteolytic breakdown and increases the biological half-life of the interferon protein" http://en.wikipedia.org/wiki/Peginterferon_alfa-2b " In Pegasys, a large, branched, mobile PEG is attached to the interferon alfa-2a molecule, providing a selectively protective barrier against rapid absorption, metabolism and elimination" http://www.medilexicon.com/drugs/pegasys.php Well, you asked.
Avatar f tn I start pegasys in July. Are the side effects really bad? I know everyone is different.. Do most people lose some of their hair? I just wanted info from someone that has been on this.
Avatar f tn The half-life of a drug is how long it takes for half of it to be eliminated from the bloodstream. Hope that helps.
6298176 tn?1380134459 It has a very long half life, though I can't give you specifics. The dose and how long you were on it does factor in. Your doctor should be able to help you with your questions on this.
Avatar n tn What is the shelve life of procrit and I will be traveling and keep it in a cooler is this a problem
314554 tn?1337454119 s shorter and linear-chain PEG, Peg Intron has a half-life of 30-50 hours. (Note that NPIA or non-pegylated interferon alfa has a half-life of only 3-5 hours.) 3) …multiple-dose ribavirin half-life (298 hours) is considerably longer than the single-dose half-life (79 hours) Questions: #1 What extent does RIBA prolong the half-life of the Pegasys and the Peg Intron? #2 Am I phrasing the question right? Is this how it works?
4705307 tn?1447970322 While it is best to avoid missing doses, being 4 days late on one dose of Pegasys hopefully won't alter your treatment outcome. As far as I know there are no studies on being late with Pegasys doses. I have linked you to a couple of sites that, while not giving you any stats on missing doses in relationship to SVR, do give you some information about Pegalated Interferon and also on getting back onto schedule if you have missed a dose.
1084115 tn?1385228589 Pegasys uses a branched Peg molecule bonded to its IFN - much larger than the one PegIntron uses. I believe this is what gives it its longer half-life and probably slows its absorbtion rate.
2111792 tn?1342704627 ✏ 12.3 Pharmacokinetics ☁ Maximal serum concentrations (Cmax) and AUC increased in a nonlinear dose related manner following administration of 90 to 270 mcg of PEGASYS. Maximal serum concentrations (Cmax) occur between 72 to 96 hours post-dose. Week 48 mean trough concentrations (16 ng/mL; range 4 to 28) at 168 hours post-dose are approximately 2-fold higher than week 1 mean trough concentrations (9 ng/mL; range 0 to 15).
1025666 tn?1253316691 My husband has used it twice but unfortunately still was a non responder. The last time he used it, he was on TX for 15 months and approx half (the last half) was Infergen . The started on Pegasys but switched when they couldn't get him undetectable. Well, it isn't bad at first but it sure has a wearing down effect in the long run. I think they all do actually. Joe's hgb was extremely low despite lots of Procrit so he felt quite bad the whole time.
2080475 tn?1332126191 decided to quit taking it on a monday felt fine all week untill sun when i went into serious withdrawl! so as far as half life im not sure? but you can bet i was back on it mon! so i guess it was in my system for 6 days after i stopped. p.s.
Avatar f tn ?? Does anyone know the Half life of SUBOXONE - Beprenorphine.? I HEARD it was 70 hours, but that's what I heard....unsure if that is even accurate?
535882 tn?1396576685 whats the half life for syntriod. about how much time does it take to build up in you and also leave your system?
Avatar m tn Apart from that the price of Exxura is just half of Pegasys, where earlier there was a offer with Pegasys, i.e buy one get one . But because of global pricing the offer was withdrawn by Roche & Pegasys name has changed to EXXURA.
Avatar m tn WOW, I don't really remember this side but sometimes about an hour after dosing (GS5885,GS9451,SOC) my eyes are on fire. They feel like they are shooting fire. I put the drops in and that does sooth it but initially it burns like crazy, I can almost hear them sizzle. Has anyone else exp. this? Also, the skin around my oral cavities, (yes, down- there) burn like I am eliminating toxic nuclear waste. Itching was bad last night. Better today. Newaz, wk 12 shot was Tuesday.
592046 tn?1257439712 I recently completed the Pegasys interferon/ribavirin therapy with great results so far -- viral load is undetectable so I responded. Now I wait for the 6 mos. to see if I've sustained. Have high hopes. I did the non-pegylated therapy back in 2001 and failed. Fingers are crossed! I wish I had found this forum when I first started. It was a long cold winter during therapy. Glad to know I'm not alone.
Avatar f tn Fridays shot was short on the Interferon because I pushed to much out when doing the air bubbles I did get some of it but not the full dose should I take this weeks shot early or am I in big trouble now? I never have missed a dose so unsure what to do I don't think maybe I got half the dose I will pay attention in the future if I haven't messed things up.
144210 tn?1273088782 After intravenous administration, the terminal half-life of PEGASYS in healthy subjects is approximately 60 hours compared to 3 to 4 hours for standard interferon. A mean elimination half-life of 160 hours (84-353 hours) at primary elimination phase was observed in patients after subcutaneous administration of PEGASYS.
442340 tn?1326817417 Hi All, Well it looks like my docs office wants to treat me with Peg Intron (80 mg) and Ribaviron 1000mg tablets. She said the Peg Intron in her experience causes a more "predictable" decline in red blood cells than pegasys. I am only 110 lbs, so she said because it is weight based too, that is better for me. Any thoughts on Pegasys vs. Peg Intron? My stats again - female, mid 20s, type 3a, VL 950,000. I have been infected since birth (my mom was HCV). Thanks!