Pegasys administration
Common Questions and Answers about Pegasys administration
pegasys
For example, instead of having 15% chance of cure with pegasys alone, one could have maybe 20% (or 25%) chances of cure if pegasys would be combined with 520.
Pegasys can cause substantial side effects though...pegasys + 520 could be even tougher on side effects....so the question is how much one would be willing to take a risk to get to a cure.
Above is just my own estimate (based also on consultation with studyforhope, and the fact that 520 can lower hbsag just by 0.
VRUS) has received fast track designation from the U.S. Food and Drug Administration (FDA) for PSI-7977 for the treatment of chronic hepatitis C virus (HCV) infection. PSI-7977 is an oral uridine nucleotide analog polymerase inhibitor of HCV. Pharmasset recently completed dosing in a 28 day Phase 2a trial to evaluate PSI-7977 in combination with Pegasys (pegylated interferon) plus Copegus (ribavirin) in treatment-naive patients chronically infected with HCV genotype 1.
To my knowledge there aren’t any issues with concurrent use of suboxone and IFN therapy.
Here is what I found for Incivek or Victrelis in combo with Pegasys, Ribavirin and Simvastatin. Both PIs are contraindicated.
I am on week 22, incivek done.
I take my RIBA at 5pm, I have found if I take it much later, I do not sleep well.
I take my shot Friday night at 9:00pm. I have been up a couple times with body aches, Mostly i just get pretty tired within an hour or so and usually sleep through the night. The first few weeks I did not.
Saturdays are usually ok, just tire out. Pegasys actually takes 72 to 96 hours to reach it's maximum.
00 am and 9:00 pm. The Pegasys shot on Friday night.
I need to know how to incorporate the Victrelis into the schedule.
I realize how important it is to take Victrelis at same times everyday.
Any other tips to make treatment more bearable would be appreciated.
SPLENIC RUPTURE
SPLENIC RUPTURE, INCLUDING FATAL CASES, HAS BEEN REPORTED FOLLOWING THE ADMINISTRATION OF NEUPOGEN. INDIVIDUALS RECEIVING NEUPOGEN WHO REPORT LEFT UPPER ABDOMINAL AND/OR SHOULDER TIP PAIN SHOULD BE EVALUATED FOR AN ENLARGED SPLEEN OR SPLENIC RUPTURE."
http://www.neupogen.com/pi.html#warnings
" My WBC actually dropped back to 1.2 and this is with me on Neupogen.
Pharmacokinetics
Maximal serum concentrations (Cmax) and AUC increased in a nonlinear dose related manner following administration of 90 to 270 mcg of Pegasys. Maximal serum concentrations (Cmax) occur between 72 to 96 hours post-dose.
The nurse gave me the Pegasys injection intramuscular in my arm instead of subcutaneous? Will that have any effect on the course of treatment? Does it have the same efficacy?will I still benefit from the injection in the same intended way?
I came from Afghanistan .I want to buy pegasys because it wouldnt found in my country, How can I get pegasys ???
then he recommend Pegasys, injection po siya for 48 weeks, Salamat sa Dios kasi he lead me to my new Dr. I believe that God has a plan for all of us. inform you guys what will happen. after I'm going on my third week now taking this medicine after the fourth week I will have my sgpt test. I will update you guys on the result.
Make sure you emphasize that there are floating particles in the Pegasys. A light yellow color is normal but floating particles are not.
Drug company literature states (see page 2)
http://www.medhelp.org/posts/show/638650?post_id=post_3464276
1. DO NOT USE Pegasys if it is cloudy,
2. DO NOT USE Pegays if it has particles in it.
3. DO NOT USE Pegasys if it is any color but clear or light yellow.
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