Necrotizing pancreatitis occurs when digestive hormones produced by the pancreas begin to digest the pancreatic tissue, and can lead to death.
2009, the FDA issued a safety alert that linked sitagliptin
, the active ingredient in
Januvia and Janumet, to acute pancreatitis. There were no safety studies conducted in people who have a history of pancreatitis, and the agency warned that it is not known whether these people are at an increased risk if they take sitagliptin.