However, the generic, butorphanol tartrate nasal spray, is still being produced and distributed by three manufacturers -- Novex, Mylan, and
Roxane . Butorphanol is an opioid analgesic (pain killer). It is administered through injection or nasal spray. For Migraine, it is sometimes prescribed as a rescue medication for times when abortives don't work or in place of abortives for Migraineurs who cannot take them..