Tylenol does not affect INR but is not as good of a pain
reliever for most people as the NSAIDS (ibuprofen, advil). NSAIDS are great for pain
and inflammation, but inhibit platelets and increase the risk of bleeding. Like anything in life, you have to do a risk / benefit analysis to decide if it is worth it and your doctor should be involved. Example, if you are a 40 year old person with no medical problems and have osteoarthritis, the risk of bleeding with NSAIDS may be acceptable.