Nitrofurantoin renal dosing
Common Questions and Answers about Nitrofurantoin renal dosing
macrobid
Please note Tenofovir is principally cleared through the kidney and dosing adjustments due to renal impairment have not been clinically tested.
The followings are extracts from the label information for Tenofovir:
2.3 Dose Adjustment for Renal Impairment in Adults
Significantly increased drug exposures occurred when VIREAD was administered to subjects with moderate to severe renal impairment [See Clinical Pharmacology (12.3)].
I am not aware that impaired renal function precludes treatment for HCV. I have read that kidney disease is a negative predictor of SVR but, so too are a lot of conditions yet people have overcome them. I have seen articles which discuss the plasma levels of ribavirin with renal impaired patients. The suggestion is that rather than weight base dose these patients the dose should be arrived at by considering GFR (glomerular filtration rate).
This is from Clinical Care Options @ http://tiny.
Looking for some advice, have had a kidney infection on and off for the last two months, i have been on four weeks of different antib's and have had renal ultra sound. Ultra sound came back clear. Was back at doc today with the same symptoms, no blood was found in urine sample, just acidic levels were not normal also protein found. I was prescribed antib's but only to take if things get worse, ie temp continues and back pain.
Regular consumption of citrus fruits like oranges also helps in preventing recurrent UTI as they cause acidification of the urine. You will also need continuous prophylaxis with drugs like nitrofurantoin to prevent UTI. This may go on for 6-12 months. It’s good to know that your renal functions are good. Please do discuss with a urologist. Wishing you good luck. I sincerely hope that helps. Take care.
By "AGE" I'm assuming you mean a persons age in years. I don't believe age has anything to do with Janumet's "effectiveness" but age has a larger role with renal function. To make it clear for other readers, Janumet is combination of two drugs; Sitagiptin and Metformin.
This a brief from the Merck web site - makers of Janumet - Section 8.5 - Geriatric Use JANUMET.
I also have kidney damage from a bout of high blood pressure 4 years ago, and I am a frequent kidney stone former, so I am being watched carefully by a nephrologist too. I have renal panels frequently too. I was wondering if any of this could increase my stone risk. I was reading about the cytomel and stones. The nephrologist wants me to remain on the synthroid and cytomel.
I have been prescribed nitrofurantoin (macrobid) for a UTI. I have a hard time swallowing pills. Can these be broken up?
I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference:
According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.
Other reasons necessitating surgical intervention are failure of renal growth, formation of new scars, renal deterioration and VUR in girls approaching puberty.
There are three types of surgical procedure available for the treatment of VUR: endoscopic (STING/HIT procedures); laparoscopic; and open procedures (Cohen procedure, Leadbetter-Politano procedure).
It also says that the colony count of the bacteris is 1,00,000 cfu/ml. Hence, doctor prescribed some medicines like Uribid with nitrofurantoin in it, Prothiaden M, Montemac FX for allergy and Hifenac-P for fever and also Cital syrup for UTI. My mother continued the course for one week, now fever and tiredness have decreased, but the burning sensation continues. Is this mixture of tablets fine, or any other suggestion or recommendations for treating this urinary tract infection of K.Oxytoca.
Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required. The normal ranges of GFR, adjusted for body surface area for males is 70 ± 14 mL/min/m2 (56-84) . Risk factors for kidney disease include diabetes, high blood pressure, family history and older age.
Take care and keep us posted.
9 days ago Nitrofurantoin (200g a day for 5 days) was taken and daily birth control (Qlaira). Both are known to decrease levels of haptoglobin but nothing about complete depletion.
Could this be an extended effect from Nitrofurantoin? When should the test be repeated ?
A couple of weeks later I developed a urinary tract infection. Urologist prescribed nitrofurantoin for the infection. Immediatedly after starting the antibiotic my ears gradually starting feeling clogged. Now, two weeks later, they are both very clogged (no wax buildup) and I can barely hear. Logic tells me the ear clogging is somehow connected to the nitrofurantoin. Has anyone ever experienced this or heard of this happening? Will this clogging go away by itself?
I have recently been feeling unwell and have recurring UTI’s and been on Nitrofurantoin. I also take levothyroxine for an under active thyroid.
I recently had a LFT and my ALT was 934. My GGT was 140 and bilirubin 37.
I am having an urgent scan tomorrow but the drs seem at a loss as to what is causing this? Any advice or help?
now, on the 21st may this week my partner had a uti. doc gave her 3 days of nitrofurantoin but it still hasnt gone.
im worried ive infected her with something, but not sure about the timescales.
am i going crazy, i was obssessed that I had gonorhhea until the test came back negative. now im thinking ive caught something else!
she had no symptoms before this week.
I visit the doctor again and she gave me Nitrofurantoin antibiotics and after taking them once, instantly my erections returned and tests returned to normal size -I am taking 100mg twice in a day . The next day I woke up and my erections were gone again and testes shrunk, I took Nitrofurantoin and nothing is happening . I’m so scared I have phoned 111 and told them this and they told me to
Go to my doctor again - the doctor said she gave me antibiotics already and refused to see me !
I have been taking ciprobid, doxyl and nitrofurantoin for a month now. but still the is no change. I still have some pains. I was diagnosed with an UTI, in the urine and blood test the was no Chlamydia, gonorrhea or syphilis in short no STI. But and the doctor, prescribed ciprobid, doxyl and nitrofurantoin for me and my wife. I have visited the doctor 3times and the last tested I did.
There are preferred opiates drugs that are use in patients with liver disease that have shorter half-lives and have less harmful side effects on the renal system. Your liver doctor should be aware of these drugs and be able to determine if you may be able to use them.
With regards to OTC medications, normal recommended doses of acetaminophen can be safely given to patients who suffer from cirrhosis in the short term.
(My weight is about 145 kg, previously has been 188 kg, with a length of 170cm) It started in 2006, I did get nitrofurantoin, but I got only more ill, till I even got over 41 degree fever and an emergency-doctor then prescribed ciprofloxacin which did help (this was in Holland). Since 2008 we are in UK and I have been under treatment at St George, London, till 2010.
But regarding this Vit D , should i need to take along with calcium supllements Or no need? I have renal stones of 0.5mm. Does this have any effect on this?
If you are stage 3 you can take any analgesic within dosing limits. Your liver function has not been altered by your liver disease yet. If you become stage 4 (cirrhosis) then you will have to modify what drugs you can take because the liver is no longer able to process drugs in a normal manner.
Tramadol is an synthetic opiate and should not be taken for "mild" pain.
ve also got a case of epididymitis (nuts on fire). Current antibiotic is Nitrofurantoin Macro. Urologist told me to come back in 3 months while my health and quality of life *****!!! What are some other options for treatment? Original culture was Coagulese negative Staph.
Most uncomplicated UTIs can be treated with oral antibiotics such as trimethoprim, cephalosporins, nitrofurantoin, or a fluoroquinolone (e.g., ciprofloxacin or levofloxacin). Trimethoprim is probably the most widely used antibiotic for UTIs and is usually taken for 7 days. It is often recommended that trimethoprim be taken at night to ensure maximal urinary concentrations and increase its effectiveness.
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