Nisoldipine pka

Common Questions and Answers about Nisoldipine pka

sular

Furthermore, the impairment of cell proliferation was demonstrated to be linked to induction of the inhibitory protein kinase A (PKA) pathway by HIV proteins. This induction of PKA was accompanied by an increase in intracellular cAMP, which is necessary for the activation of PKA. Finally, increases in cAMP/PKA activity were shown to induce biochemical changes that impaired proliferation when cells were stimulated with phytohemagglutinin.

Uric acid has 4 ionizable hydrogen ions (positions 1, 3, 7, and 9). Only the hydrogen ion on position 9 (pKa = 5.8) is ionizable at physiologic pH. Sodium urate is 15 times more soluble than uric acid. When pH equals pKa (5.8), uric acid and sodium urate are present in equal quantities. As pH increases, the ratio of sodium urate to uric acid increases. At a pH of 6.8, 10 times more sodium urate is present than uric acid; whereas, at a pH of 7.

Coadministration with the hepatitis C virus (HCV) NS3/4A protease inhibitors, boceprevir and telaprevir, may increase the plasma concentrations and pharmacologic effects of calcium channel blockers, especially the dihydropyridines (e.g., amlodipine, felodipine, nicardipine, nifedipine, nisoldipine). The mechanism involves inhibition of intestinal and hepatic CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of most calcium channel blockers.

nimodipine (Nimotop), felodipine (Nitrendipine, Plendil), nisoldipine (Sular), nicardipine (Cardene), verapamil (Verelan) Psychiatric medications: buspirone (BuSpar), triazolam (Halcion), carbamazepine (Tegretol), diazepam (Valium), midazolam (Versed), sertraline (Zoloft) Intestinal medications: cisapride (Propulsid) taken off the U.S.

sildenafil, tadalafil Hormone replacement: cortisol, estradiol, methylprednisolone, progesterone, testosterone Immunosuppressants: cyclosporine, sirolimus, tacrolimus HMG-CoA reductase inhibitors: atorvastatin, fluvastatin, lovastatin, simvastatin Opioids: alfentanil, fentanyl, sufentanil Selective serotonin reuptake inhibitors: fluvoxamine, sertraline Xanthine: theophylline

calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Covera, Isoptin, Verelan);carbamazepine (Tegretol); diuretics ('water pills'); medications for mental illness such as haloperidol (Haldol); methyldopa (Aldomet); metronidazole (Flagyl); nonsteroidal anti-inflammatory medicat

carvedilol Calcium channel blockers: diltiazem, felodipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil Erectile dysfunction drugs: sildenafil, tadalafil Hormone replacement: cortisol, estradiol, methylprednisolone, progesterone, testosterone Immunosuppressants: cyclosporine, sirolimus, tacrolimus HMG-CoA reductase inhibitors: atorvastatin, fluvastatin, lovastatin, simvastatin Opioids: alfentanil, fentanyl, sufentanil Selective serotonin reuptake inhibitors: fluvoxamine, sertral

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