Narcolepsy in systemic lupus erythematosus
Common Questions and Answers about Narcolepsy in systemic lupus erythematosus
narcolepsy
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*Serological profile and clinical features of nucleolar antinuclear pattern in patients with systemic lupus erythematosus from southwestern Spain. Lupus 2016 Aug;25(9):980-7. doi: 10.1177/0961203316629557
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I have Hashimoto's thyroiditis as well. That was my last autoimmune disease to show up..hopefully my last! I also have autoimmune pernicious anaemia, vitiligo and alopecia areta (last one in remission).
Excerpt from Patient UK - Hashimoto's thyroiditis...
Systemic lupus erythematosus (lupus or SLE) - over 95%
Progressive systemic sclerosis (scleroderma) - 60-90%
Rheumatoid Arthritis - 25-30%
Sjogren's syndrome - 40-70%
Felty's syndrome - 100%
Juvenile arthritis - 15-30%
- excerpt from "ANA (Antinuclear Antibody) Test" By Carol Eustice
Elevated complement CH50 can be indicative of:
Ulcerative colitis
Infections
Cancer
Low complement CH50 can be indicative of:
Malnutrition
Kidney transplant rejection
Heredity angioedema
C
The PTPN22 gene increases the risk of type 1 diabetes, rheumatoid arthritis, autoimmune thyroid disease, systemic lupus erythematosus, vitiligo. Alopecia areata often occurs in people whose family members have other autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis, thyroid disease, systemic lupus erythematosus, pernicious anaemia, or Addison's disease.
sDNA is highly diagnostic of systemic lupus erythematosus (SLE) and implicated in the pathogenesis of lupus nephritis (inflammation of the kidney caused by SLE). High calcium can be seen with SLE due to either the immune system targeting the parathyroid glands (extremely rare) or more commonly due to kidney problems.
The homogenous pattern is associated with systemic lupus erythematosus and mixed connective tissue disease. The speckled pattern is associated with systemic lupus erythematosus, sjogren syndrome, scleroderma, polymyositis, rheumatoid arthritis, and mixed connective tissue disease.
The systemic lupus erythematosus (SLE) could be causing the symptoms you described. Systemic Lupus Erythematosus (SLE) can affect the skin, musculoskeletal, heart, kidneys and the brain.
In lupus the blood counts (red blood cells, white blood cells and platelets) are low, positive antinuclear antibodies in the blood, increased sedimentation rates and increased C reactive protein. Diagnosis of Lupus is a combination of clinical symptoms and tests and there are '11' criteria.
When internal organs are involved, the condition is called systemic lupus erythematosus (SLE). Both discoid and systemic lupus are more common in women than men.
Common complaints and symptoms include fatigue, low-grade fever, loss of appetite, muscle aches, arthritis, ulcers of the mouth and nose, facial rash ("butterfly rash") and photosensitivity to light.
What are the symtoms of both diseases that you wrote about (IgA nephropathy or Systemic lupus erythematosus)? He does have Diabetes, High Blood Pressure and blocked arteries in his heart.
The common causes of passing proteins in urine are diabetes, hypertension, cardiovascular disease, kidney infections, kidney diseases,hypertension,systemic lupus erythematosus etc.I suggest that you should consult your treating doctor and clarify your concerns. Any test result must be correlated clinically. This is merely an advice and not a substitute for clinical examination. Treatment will depend on the underlying cause. Hope it helps.
Best wishes and regards!
"A nucleolar pattern of the ANA is seen not only in SLE but also in inflammatory myositis and systemic sclerosis." - Rheumaknowledgy - Systemic Lupus Erythematosus (SLE)
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"C3 and C4 are blood proteins that are involved with the immune response. Lupus is a disease that involves immune hyperreactivity and thus levels of these proteins can be low in active lupus as they are consumed. C4 can be low without C3 also being low.
Antinuclear antibodies (ANAs) are found in patients with systemic lupus erythematosus (SLE) and other connective tissue diseases. Anti SSA have been detected with high frequency in patients with Sjögren's syndrome.
Hope this helped and do keep us posted.
Thanks for your reply. I am much relieved now.
Just to add, the non thyroidal illness condition is called by a few names in medical literature but most commonly Euthyroid Sick Syndrome (ESS) although other names can be used such as Non-thyroidal Illness Syndrome (NTIS) and Low T3 Syndrome.
'In SLE group, 20% had euthyroid sick syndrome, 20% had hypothyroidism (10% subclinical and 10% biochemical), and 10% had hyperthyroidism (5% subclinical and 5% biochemical).
Lung nodules can occur due to local causes like recurrent lung infections and sometimes due to cancer of the lungs. They can also be seen in systemic diseases like systemic lupus erythematosus, rheumatoid arthritis, sarcoidosis and scleroderma. Further evaluation will be based on whether the nodule is changing in size and systemic symptoms. A PET scan and biopsy may help in evaluation. A biopsy facilitates a histologic study of cells, which gives you a definite diagnosis.
The ANA titers mentioned are significant for systemic lupus erythematosus (SLE). Plaquenil is indicated for therapy in patients who have not responded satisfactorily to drugs with less potential for serious side effects. So, discuss this with your doctor, he may prescribe alternate medications for SLE.
Hope this helped and do keep us posted.
Triggers for anti-chromatin autoantibody production in SLE. LUPUS Dec. 2002, Sage Journals
"Chromatin Antibody plays a central role in the autoimmune response in systemic lupus erythematosus (SLE). Approximately 90% of patients with SLE have sera that will exhibit reactivity to nucleosomes."
---Source: Quest Diagnostics
Patients with positive Scl-70 and/or Chromatin auto-antibodies do not necessarily have SLE, Scleroderma
or other autoimmune disease.
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