Narcolepsy hypocretin

Common Questions and Answers about Narcolepsy hypocretin

narcolepsy

Avatar f tn Emerging treatments being investigated for narcolepsy include hypocretin replacement, hypocretin gene therapy, stem cell transplant, skin temperature manipulation and immunotherapy, but further research is needed to confirm their effectiveness. So, discuss the various options with your doctor and hope you find a balance. Hope this helped and do keep us posted.
Avatar n tn The combination of this study and my first MSLT nap study produced a perfect pattern for diagnosis of Narcolepsy. Has there ever been a study to look at the coorelation between the 2 diseases. Would many CFS sufferers be classified narcoleptic if they took the appropriate test? Narcolepsy leads back to hippothalmus and lack of production of hypocretin/orexin(?). Seems like all things lead to hippothalmus. Thank you!
Avatar n tn Hi, welcome to the forum. Your history is suggestive of narcolepsy. In this condition there will be excessive daytime sleepiness. In this condition there will be “automatic behavior" such as driving past a highway exit or writing off a page, with no memory of the previous few minutes. Classical narcolepsy constitutes of Hypnagogic hallucinations, Sleep paralysis and Cataplexy (emotionally triggered muscle paralysis resulting in partial or complete collapse).
Avatar m tn Hi, welcome to the forum. Your history is suggestive of narcolepsy. In this condition there will be excessive daytime sleepiness. In this condition there will be “automatic behavior" such as driving past a highway exit or writing off a page, with no memory of the previous few minutes. Classical narcolepsy constitutes of Hypnagogic hallucinations, Sleep paralysis and Cataplexy (emotionally triggered muscle paralysis resulting in partial or complete collapse).
535822 tn?1443976780 A new review published in the journal Public Library of Science ONE confirms that Pandemrix, a swine flu vaccine produced by drug giant GlaxoSmithKline (GSK), is responsible for causing an up to 1700 percent increase in narcolepsy among children and teenagers under 17 years of age. Based on their findings, a cohort of scientists has determined that narcolepsy rates increased significantly following mass vaccination campaigns with Pandemrix.
Avatar m tn What you suffer from is probably narcolepsy, which is a neurological disorder. This is thought to be caused by low protein called hypocretin, which is made in the brain. The symptoms are an urge to sleep especially after meals. Sleep studies and EEG are done to rule out other causes of poor sleep and insomnia. Eating light and frequent meals during the day helps. Also assigning a nap time during the day often helps. You can take a light meal before this.
Avatar n tn I have recently been diagnosed with narcolepsy. For years, I have suffered from EDS muscle weakness that has become worse as I have aged (mid-40's). In the beginning, I blamed it all on being single and burning the candle at both ends (20's); then being a new parent (30's) and then being a single mom to a child with narcolepsy and a preteen (now 40's). I was told I have mild cataplexy.
Avatar m tn What you suffer from is probably narcolepsy, which is a neurological disorder. This is thought to be caused by low protein called hypocretin, which is made in the brain. The symptoms are an urge to sleep especially after meals. If the symptoms are not very prominent then you may just feel fatigue and a need to lie down. Sleep studies and EEG are done to rule out other causes of poor sleep and insomnia. Eating light and frequent meals during the day helps.
Avatar f tn Hi, welcome to the forum. Your history is suggestive of narcolepsy. In this condition there will be excessive daytime sleepiness. But in your case it seems milder form of it. In this condition there will be “automatic behavior" such as driving past a highway exit or writing off a page, with no memory of the previous few minutes. Classical narcolepsy constitutes of Hypnagogic hallucinations, Sleep paralysis and Cataplexy which is not seen in your case.
Avatar m tn Hi, welcome to the forum. Your history is suggestive of narcolepsy or hypersomnia. In this condition there will be excessive daytime sleepiness. In this condition there will be “automatic behavior" such as driving past a highway exit or writing off a page, with no memory of the previous few minutes. You need to undergo tests like Polysomnography, Multiple Sleep Latency Test and CSF levels of Orexin/Hypocretin which help to substantiate the diagnosis.
Avatar f tn What you suffer from is probably narcolepsy, which is a neurological disorder. This is thought to be caused by low protein called hypocretin, which is made in the brain. The symptoms are an urge to sleep especially after meals. Sleep studies and EEG are done to rule out other causes of poor sleep and insomnia. Eating light and frequent meals during the day helps. Also assigning a nap time during the day often helps. You can take a light meal before this.
427801 tn?1203844562 If you are positive, you will have a marker on your blood cell.
Avatar f tn Narcolepsy is a CNS disorder and is thought to also be caused by an autoimmune disorder. Causes: current thinking is that a group of cells in the brain responsible for sleep-wake behavior is damaged or absent. (gosh do you think the MS lesions might also damage this area for people unlucky to have both!) Tests: The spinal fluid of most patients with narcolepsy shows the neuroprotein lacking or deficient. The neuroprotein is "hypocretin".
9780765 tn?1405910914 I am waiting to do a sleep study next month to find out if I have narcolepsy or some other problem. The reason I am finally getting tested is I just tired and run down every single day which makes life very hard since I have 2 boys with slight disabilities and jam packed with energy. I quit work mainly to be with my boys but also because I have a hard time getting up and could not function well at work. Before seeing a sleep specialist, I thought I was only waking up a couple times at night.
Avatar f tn So, I have recently found out that my hypocretin deficiency (which is the cause of mynarcolepsy with severe cataplexy) also plays a critical role in the neuroendocring system. Namely, it reduces several pituitary hormones by 50% or greater due to a defect in the hypothalamus where the hypocretin neuropeptide is produced. The hormones that are reduced are: LH, ACTH and TSH. It also greatly reduces leptin levels. (journal of clinical endocrinology and metabolism).
Avatar f tn It is said that people who suffer from Narcolepsy lack in the protein called Hypocretin, which actually regulates the inclinations to fall asleep.
535822 tn?1443976780 75% of all vaccinated and 67 total people had narcolepsy. Heck, as a mother of young kids--- a bit of narcolepsy might be nice.
3065262 tn?1342122561 If all these are ruled out then it is possible that you have narcolepsy, which is a neurological disorder. This is thought to be caused by low protein called hypocretin, which is made in the brain. The symptoms are an urge to sleep especially after meals. Sleep studies and EEG are done to rule out other causes of poor sleep and insomnia. Eating light and frequent meals during the day helps. Also assigning a nap time during the day often helps. You can take a light meal before this.
Avatar f tn So, I have recently found out that my hypocretin deficiency (which is the cause of mynarcolepsy with severe cataplexy) also plays a critical role in the neuroendocring system. Namely, it reduces several pituitary hormones by 50% or greater due to a defect in the hypothalamus where the hypocretin neuropeptide is produced. The hormones that are reduced are: LH, ACTH and TSH. It also greatly reduces leptin levels. (journal of clinical endocrinology and metabolism).
Avatar f tn I am diagnosis with narcolepsy and have had symptoms for 5 years now. I have been taking 500 mg. of nuvigil for over 2 years. Plus, 60 mg of adderall a day. My symptoms have slowed down a little, but I have to take 2 naps a day and not drive anywhere. I have sleep studies twice a year and it seems to get worse each time. Its very aggravating to me! It seems like something would help. I see a team of specialists at Vanderbilt, but I need something else, but what? Anyone have any suggestions?
1287446 tn?1313947638 Hi everyone. I am not familiar with Narcolepsy or sleep disorders in general but my sleep has always been different. Typically, I fight daytime sleepiness with caffeine. In prior years, the caffeine has been a lot but I’ve lowered it significantly.
Avatar f tn I have Narcolepsy- My vitamin B 12 level is 235- should it be higher for my condition?
Avatar f tn Although the pt has RLS and PLMS, the arousal associated with these do not likely explain EDS- given a short overall sleep and REM latency, consider narcolepsy clinically. I had 156 arousals, 110 spontaneous, the rest due to limb movement. I also spent most of my sleep time in sleep stages 1 and 2, whith REM episodes scattered randomly. I had no time in stage 3, and when I had REM sleep it was from wake to REM with no progression through the other cycles.