certain possible causes of muscle twitches are muscle fatigue, anxiety, certain medicines, caffeine, stroke,
multiple sclerosis, trauma to the nerves and nervous system disorder. It may be seen in association with fibromyalgia syndrome. This need to be investigated by a neurologist and treatment would depend on the diagnosis. Certain stretching and exercise, massaging the affected muscle, medicines like klonopin may help stop the twitches and spasms.