Seizures most likely result from lesions present in the cerebral cortex and adjacent white matter of people with
multiple sclerosis. However, other factors may also play a
role — especially since such lesions are very common and seizures are unusual in MS.
Seizures have been observed before and presumably marking the clinical onset of multiple sclerosis, and during acute bouts of MS. In some cases, seizures appear to be the only sign of a flare of MS.