Morphine and histamine release
Common Questions and Answers about Morphine and histamine release
avinza
Certain factors can trigger the release of histamine and the other chemicals from mast cells and this includes drugs (especially aspirin and other non-steroidal anti-inflammatory drugs, codeine and morphine, and some anaesthetics), alcohol, emotional stress, physical stimuli (heat, exercise and friction), bacterial toxins and insect venom. Liposuction is a physical stimulus and can trigger histamine release.
I have been have been having huge histamine releases in my body (Checked by ER) to the point my whole body aches and my lungs hyper expand making it extremely difficult to breathe. I just got the results from my allergy test - NEGATIVE - Now no one seems to know what to do? Has anybody experienced this? Thanks.
I have also copied this down and for more information we have a Dermatology forum on MH Triggers for Mast Cell Disease
Physical stimuli: Exercise, heat, skin friction, hot baths, hot drinks, cold exposure (especially swimming), sunlight, emotional stress, spicy foods.
Indeed Morphine is known to trigger asthma in some ppl. Actually morphine can trigger an attack because of histamine release. Histamine is a potent bronchocontrictor thus has the potential to induce an asthma attack.
There are multiple opiates that may be more effective and appropriate for you, especially given you have asthma. I am not a physician - and to suggest a specific medication for you would not be prudent.
Took an awful long time to figure that I was SENSITIVE to morphine/codeine. After operations I went nuts with nausea and ITCHING...that dang oxygen thing up my nose!! I told them FINALLY about this that I finally had to figure out on my own and got on different anesthesia. WOW. What a difference!! Allergies imply something altogether different and one CAN develop an allergy to drugs such as morphine and THAT YOU don't want happening.
They have been unable to do the the heart surgery, because of high blood count and pain in his stomach. The pain has been consistently between 6 and 7 (10 being the worst), without morphine he has pain when breathing, moving, eating and/or drinking. They have done a biopsy of his stomach and it's normal. They have done ultrasounds of the stomach and it's clear. They have checked his liver and it's clear.
What is MS Contin and what is MS/IR. They are both morphine? Does the Contin mean extended release and the IR mean immediate release. The MS/IR also has the letters IMN REO. I'm trying to find out if the MS/IR can be cut in half for tapering. Thanks to all that reply.
On yahoo answers...... (sounds good)
"You've got lots of good advice here and I just had to add mine because I suffer from hives-- diagnosed as 'ideopathic urticara'- for months at a time.
The best advice my dermatologist ever gave me: Don't scratch. When you scratch your cells burst and release histamines... you may find yourself swollen. I have had this condition to the point of being disfigured and in the ER being pumped full of steroids.
Morphine is a terrible one to quit ct....and I doubt that the Doc would want to prescribe enough Norco's to do the job...make certain the taper is long and slow....nausea and vomiting are solid w/d symptoms. Stay well hydrated unless you like your fluid I.V. - most of the MS prescribed outpatient these days is MSContin - morphine sulfate continuos release.
He was very nice and helpful. He gave me morphine extended release 30mg tables and I need to take those 3x a day. I asked him about pregnancy and this medication. He said that there is always a chance of compilations. He said he has seen several patients that have gotten pregnant on this medication, some have tapered off of it and some continued to stay in this medication.
I have this 10 mg methadone pills,the morphine 100 mg extended release(Its a capsule,so I can open it and measure approximately,and morphine 30 mg immediate release.
I really hate the sweating of the abstinence,is there something that helps it?what other drug(benzos or else)can help me to stop?
I have time, and I'm not running out of the meds,but really want to quit...help!!!
Yes- there is extended release morphine- HOWEVER- you can not and should NEVER cut/bite/half extended release medications. They are meant to deliver a consistent level of medication over a specific time period. Cutting/biting/breaking them in half dumps the entire dose into your system at one and can result in exactly what you are experiencing - and accidental overdose/death.
I have been taking 60 mg. extended release morphine twice daily for 3.5 months. I have had issues for 30 years with anxiety and depression but it flared up almost immediately after I began the morphine. Normally the anxiety resolves itself within a few weeks but this time it has persisted and continues on. Could it be caused by the morphine? This is my thought but the pharmacist said he didn't think it was.
Also my doctor is suggesting 8 tylenol a day to replace the morphine.
Quercetin inhibits the production and release of histamine and other allergic/inflammatory substances. Histamine is a substance that is responsible for the allergic symptoms in the body. It can be taken in natural form by consuming apples and red onions and is also available as a dietary supplement.
You may discuss this with your healthcare provider for dosage and other instructions.
Some opiates cause histamine release-- particularly morphine-- that can cause itching and a rash. Some high-potency synthetic opiates--namely fentanyl and sufentanil-- cause facial itching, particularly around and inside the nose. Some medications can cause a feeling of extreme restless called 'akathesia' that sometimes presents as intense itchiness over the body, especially the legs.
Hives develop in response to an allergic reaction, by the release of histamine. The allergen can be medications, food, extremes of temperature, exercise and viral infections to name a few. Since you developed the outbreak along with joint pains and fever, it could be a response to an infection. So, therapy lies in resolving the infection and anti-histamines. If the present antihistamines are not very effective you can consult your doctor for long acting ones.
Hi meg,
Oxycontin is just oxycodone in extended release form. It is no more powerful than immediate release oxycodone. And morphine is actually less powerful than oxycodone. Oxycodone is 1.5-2 times stronger than morphine. The shape of a pill and whether the pill is a tablet or capsule does not tell you if it is extended release or immediate release. Avinza is extended release morphine than comes in capsules versus tablets.
When ever you are exposed to allergen there will be release of histamine, this is responsible for raised lesions on skin leading to itching. The order may differ from individuals to individuals.
You need to identify such allergen and prevent further exposure. Oral anti histamines and low potency corticosteroids will help to reduce the symptoms. I suggest you to consult allergy specialist. Take care and regards.
Hydromorphone and fentanyl appear to be the least affected by renal dysfunction, and fentanyl has less hemodynamic disturbance (due to lack of histamine release associated with other opioids).39"
"NSAIDs and opioids may be used at reduced doses in patients with chronic liver disease without cirrhosis. Patients with cirrhosis have fewer analgesic options.
I've been taking Morphine Sulfate 15mg. slow release tablets for 2 weeks. The back pain I had is gone and I want to stop taking the Morphine. Is it safe to stop or do I have to wean off of it? I also have the quick release 15mg. of Morphine which I haven't had to use. Will I have some sore of reaction if I stop cold turkey?
Whenever you are exposed to allergen there will be release of histamine, this is responsible for sneezing first and then followed by further release of histamine in the skin leading to itching, runny nose, watery eyes etc. The order may differ from individuals to individuals.
You need to avoid contact with allergen to avoid further complications. Also treatment includes anti histaminic and glucocorticoids against prescription.
My pain management doctor took me off the fentanyl patch after I had complained about feeling "loopy" all the time and breaking out from the patch, He then prescribed morphine 15mg extended release 2 times a day. Anyway, I had a gastric bypass weight loss surgery in 2008 and I remembered the Doctor saying to me that extended release medication will not be effective anymore because of the intestines being cut or shortened.
The mast cell tissue release Histamine which spread to the air by some ways which cause allergic phen—.And I think the mast cell tissue is highly related to brown adipose tissu.Brown adipose is distributed in scapula,shoulder,neck, perineumIt.So,you might feel burning and scratch frequently in these place.Generally,I thought the instinct of PATM caused by histamine is immune system problem.So lots of people also suffer from rheumatic arthritis when they grow old.
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