I should add that the porta potty theory of vitamins probably does apply to time-release supplements. There's only so much time the body is going to take to digest anything, and then it's going to evacuate it, and that's before time release vitamins release. Still, you'll get something, not nothing. And if you're on medication, be careful with milk thistle. All medication is toxic to some degree, and milk thistle may remove some of it before it can be absorbed.